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U5625

Uridine 5′-diphosphoglucuronic acid ammonium salt

98-100%, from Saccharomyces cerevisiae, powder

Synonym(s):

UDP-GlcA, UDPGA, Uridine-diphosphate-glucuronic acid ammonium salt, Uridine[5′]diphospho[1]-α-D-glucopyranosuronic acid ammonium salt

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100 MG

$449.00

250 MG

$835.00

500 MG

$1,470.00

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$2,450.00

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O18P2 · xNH3
CAS Number:
43195-60-4
Molecular Weight:
580.29 (free acid basis)
UNSPSC Code:
41106305
PubChem Substance ID:
24900657
NACRES:
NA.51

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Product Name

Uridine 5′-diphosphoglucuronic acid ammonium salt, 98-100%

biological source

Saccharomyces cerevisiae
enzyme from bovine liver (catalase)
enzyme from rabbit muscle (LDH)

Quality Level

200

assay

98-100%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

N.O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.H3N/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);1H3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;/m1./s1

InChI key

WMWKTCPGFOEPBD-YGIWDPDDSA-N

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1 of 4

This Item
U5252U6751U4375
Uridine 5′-diphosphoglucuronic acid ammonium salt 98-100%

Sigma-Aldrich

U5625

Uridine 5′-diphosphoglucuronic acid ammonium salt

Uridine 5′-diphospho-N-acetylgalactosamine disodium salt ≥97%

Sigma-Aldrich

U5252

Uridine 5′-diphospho-N-acetylgalactosamine disodium salt

Uridine 5′-diphosphoglucuronic acid trisodium salt 98-100%

Sigma-Aldrich

U6751

Uridine 5′-diphosphoglucuronic acid trisodium salt

Uridine 5′-diphospho-N-acetylglucosamine sodium salt ≥98%

Sigma-Aldrich

U4375

Uridine 5′-diphospho-N-acetylglucosamine sodium salt

biological source

Saccharomyces cerevisiae, enzyme from rabbit muscle (LDH), enzyme from bovine liver (catalase)

biological source

synthetic (organic)

biological source

bovine liver, rabbit muscle, yeast

biological source

bakers yeast

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

assay

98-100%

assay

≥97%

assay

98-100%

assay

≥98%

form

powder

form

powder

form

powder

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Uridine 5′-diphosphoglucuronic acid (UDPGA) is a cofactor, synthesized from UDPglucose and nicotinamide adenine dinucleotide (NAD+) intracellularly by the catalytic activity of UDPglucose dehydrogenase. The concentration of UDPGA in a number of liver preparations ranges from 0.3-0.5 mM.[1]

Application

Uridine 5′-diphosphoglucuronic acid ammonium salt has been used in the initiation of UDP-glucuronosyl transferase (UDGPT) assay towards 14C-testosterone in the liver S9 protein.[2] It is suitable for use in UDGPT assay.[3][4]

Biochem/physiol Actions

Uridine 5′-diphosphoglucuronic acid (UDGPA) is the glucuronic acid donor for the conjugation of bilirubin in the endoplasmic recticulum.[5]

Pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000516182
0000516182
0000501371
0000501365
0000501366

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Seasonal testosterone UDP-glucuronosyltransferase activity and biliary steroids in Eurasian perch: Response to leachate exposure
Linderoth M, et al.
Ecotoxicology and Environmental Safety, 68(1), 49-56 (2007)
Identification of quercetin glucuronides in human plasma by high-performance liquid chromatography-tandem mass spectrometry
Wittig J, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 753(2), 237-243 (2001)
Justine Badée et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(2), 124-134 (2018-11-28)
UDP-glucuronosyltransferase (UGT)-mediated metabolism is possibly the most important conjugation reaction for marketed drugs. However, there are currently no generally accepted standard incubation conditions for UGT microsomal assays, and substantial differences in experimental design and methodology between laboratories hinder cross-study comparison
Molly Lin et al.
Xenobiotica; the fate of foreign compounds in biological systems, 48(10), 1021-1027 (2017-08-29)
1. Glucuronidation of amines has been shown to exhibit large species differences, where the activity is typically more pronounced in human than in many preclinical species such as rat, mouse, dog and monkey. The purpose of this work was to
Shupeng Yang et al.
Journal of agricultural and food chemistry, 65(33), 7217-7227 (2017-07-25)
After being incubated with animal and human liver microsomes, metabolites of phase I and II were investigated. A comparison was performed by ultrahigh performance liquid chromatography-quadrupole/time-of-flight coupled to mass spectrometry (UHPLC-Q/TOF). Consequently, a total of four phase I metabolites and
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