U5633

Sigma-Aldrich

Ubiquitin Activating Enzyme (E1) human

recombinant, expressed in baculovirus infected Sf21 cells

CAS Number:
MDL number:
NACRES:
NA.56

Quality Level

biological source

human

recombinant

expressed in baculovirus infected Sf21 cells

assay

≥95% (SDS-GE)

form

solution

application(s)

cell analysis: suitable

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UBA1(7317)

General description

Ubiquitin Activating Enzyme (E1) is responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner.

Physical form

Solution in 50 mM HEPES, pH 8.0, 50 mM NaCl and 1mM TCEP

Other Notes

Manufactured for Sigma by Boston Biochem. Inc.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Chunmei Yang et al.
International journal of biological sciences, 16(6), 1059-1070 (2020-03-07)
Cullin 4A and 4B (CUL4A and 4B) function as oncogenes in colorectal cancer (CRC) cells. Both of them conservatively associate with DNA damage-binding protein 1 (DDB1) and DDB1-CUL4-associated factor 4 (DCAF4) to form Cullin-RING E3 ligases known as CRL4DCAF4, which...

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