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U6381

Sigma-Aldrich

Uridine

BioUltra, ≥99%

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Synonym(s):
1-β-D-Ribofuranosyluracil, Uracil-1-β-D-ribofuranoside
Empirical Formula (Hill Notation):
C9H12N2O6
CAS Number:
Molecular Weight:
244.20
Beilstein:
754902
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.26

biological source

synthetic (organic)

product line

BioUltra

Assay

≥99%

form

powder

impurities

≤0.016% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.2%

mp

163-167 °C (lit.)

solubility

H2O: 0.1 M, clear, colorless

cation traces

Al: ≤0.0005%
Ca: ≤0.01%
Cu: ≤0.0005%
Fe: ≤0.003%
K: ≤0.005%
Mg: ≤0.003%
NH4+: ≤0.15%
Na: ≤0.02%
Pb: ≤0.005%
Zn: ≤0.0005%

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

InChI key

DRTQHJPVMGBUCF-XVFCMESISA-N

Gene Information

mouse ... Uck1(22245)

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This Item
U3003U3750PHR2244
Uridine BioUltra, ≥99%

Sigma-Aldrich

U6381

Uridine

Uridine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

U3003

Uridine

Uridine ≥99%

Sigma-Aldrich

U3750

Uridine

Uridine Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2244

Uridine

assay

≥99%

assay

≥99%

assay

≥99%

assay

-

form

powder

form

powder

form

powder

form

solid

impurities

≤0.016% Phosphorus (P), ≤0.1% Insoluble matter

impurities

-

impurities

-

impurities

-

mp

163-167 °C (lit.)

mp

163-167 °C (lit.)

mp

163-167 °C (lit.)

mp

163-167 °C (lit.)

solubility

H2O: 0.1 M, clear, colorless

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL, clear, colorless

solubility

-

General description

Uridine is a pyrimidine nucleoside which is crucial for the synthesis of RNA and membranes. It helps in normal cell function and growth by forming pyrimidine nucleotide -lipid conjugates.

Application

Uridine has been used to study the functional complementation of nucleoside hydrolase from a protozoan parasite and mammalian uridine phosphorylase on URH1 (uridine hydrolase) of Saccharomyces cerevisiae.
It has been used to check the effect of chronic uridine application on liver metabolism in mice.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Customers Also Viewed

Slide 1 of 6

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Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice.
Urasaki Y, et al.
PLoS ONE, 11, e0146994-e0146994 (2016)
Purinergic and Pyrimidinergic Signalling: Molecular, Nervous and Urogenitary System Function
Handbook of Experimental Pharmacology (2013)
Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase.
Mitterbauer R, et al.
Applied and Environmental Microbiology, 68, 1336-1343 (2002)
Qi Qiu et al.
Nature methods, 17(10), 991-1001 (2020-09-02)
Single-cell RNA sequencing offers snapshots of whole transcriptomes but obscures the temporal RNA dynamics. Here we present single-cell metabolically labeled new RNA tagging sequencing (scNT-seq), a method for massively parallel analysis of newly transcribed and pre-existing mRNAs from the same
Ian E Crandall et al.
Journal of medicinal chemistry, 56(6), 2348-2358 (2013-02-16)
Resistance by Plasmodium falciparum to almost all clinically used antimalarial drugs requires the development of new classes of antimalarials. 6-Iodouridine (15), a novel and potent inhibitor of orotidine 5'-monophosphate decarboxylase (ODCase), exhibited efficacy in a mouse model infected by P.

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