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U6756

Sigma-Aldrich

U-73122 hydrate

powder

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Synonym(s):
1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione
Empirical Formula (Hill Notation):
C29H40N2O3 · xH2O
CAS Number:
Molecular Weight:
464.64 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77

assay

≥97.5% (HPLC)

Quality Level

form

powder

color

off-white

solubility

ethanol: ~0.7 mg/mL
DMSO: ~0.9 mg/mL
chloroform: ~10 mg/mL
DMSO: ≤2.6 mg/mL (Achieved with heating.)
ethanol: ≤5 mg/mL (Achieved with heating.)
H2O: insoluble

storage temp.

room temp

SMILES string

O.COc1ccc2C3CC[C@]4(C)[C@H](CCC4C3CCc2c1)NCCCCCCN5C(=O)C=CC5=O

InChI

1S/C29H40N2O3.H2O/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33;/h8,10,13-14,19,23-26,30H,3-7,9,11-12,15-18H2,1-2H3;1H2/t23-,24-,25+,26+,29+;/m1./s1

InChI key

WCOYJDRCHHGMRK-BDEPKWELSA-N

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1 of 4

This Item
U6881K1001662035
U-73122 hydrate powder

U6756

U-73122 hydrate

U-73343

U6881

U-73343

β-Estradiol-6-one

K1001

β-Estradiol-6-one

U-73122 U-73122, CAS 112648-68-7, inhibits agonist-induced phospholipase C activation (IC50 = 1-2.1 µM) in human platelets and neutrophils.

662035

U-73122

assay

≥97.5% (HPLC)

assay

≥98% (HPLC)

assay

≥98.00% (TLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

200

Quality Level

100

storage temp.

room temp

storage temp.

-

storage temp.

room temp

storage temp.

10-30°C

solubility

ethanol: ~0.7 mg/mL, chloroform: ~10 mg/mL, ethanol: ≤5 mg/mL (Achieved with heating.), DMSO: ~0.9 mg/mL, H2O: insoluble, DMSO: ≤2.6 mg/mL (Achieved with heating.)

solubility

DMSO: soluble

solubility

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless to faintly yellow

solubility

anhydrous DMSO: 1 mg/mL, chloroform: 3 mg/mL, anhydrous ethanol: 500 μg/mL

color

off-white

color

white

color

-

color

off-white

Application

U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs). U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs).

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Features and Benefits

This compound is featured on the Phospholipase C page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/ml or ≤ 5 mg/ml with heating), chloroform (approx. 10 mg/ml) and DMSO (approx. 0.9 mg/ml or ≤ 2.6 mg/ml with heating). U-73122 hydrate is insoluble in water.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Stimulation of rat pancreatic acinar cells with low concentrations of phosphatidylinositol (PI)-linked secretagogues induces [Ca2+]i oscillations, without measurable changes in the formation of inositol 1,4,5-trisphosphate. Therefore, we tested U73122 a new phospholipase C inhibitor to determine if PI turnover is
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PloS one, 6(10), e26181-e26181 (2011-11-05)
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