Ubiquilin-1 (UBQLN1) is a ubiquitin-like (UBL) protein, that contains UBL and ubiquitin-associated (UBA) domains in its N- and C-termini, respectively. UBQLN1 gene is located on the human chromosome at 9q21.32.
Anti-Ubiquilin-1 specifically recognizes human ubiquilin-1.
Anti-Ubiquilin-1 antibody produced in rabbit has been used in:
Ubiquilin-1 (UBQLN1) protein plays a major role in regulating the proteasomal degradation of several proteins including the presenilins PS1 and PS2. This protein is also involved in the degradation of cyclin A, γ-aminobutyric acid (GABA) receptor, and hepatitis C virus RNA-dependent RNA polymerase proteins. This protein might play a general role in neurodegenerative diseases. UBQLN1 genetic variants are associated with an increased risk of Alzheimer′s disease (AD). Downregulation of UBQLN1 gene modulates PS1 endoproteolysis. Downregulation of this gene is also involved in regulating the protein levels of nicastrin and presenilin enhancer 2 (PEN-2). It also increases the rate of β-amyloid precursor proteins (APP) maturation and trafficking through the secretory pathway associated with increased production of secretory β-amyloid precursor proteins (sAPP) and amyloid β (Aβ). UBQLN1 protein is associated with neurofibrillary tangles in AD brain and Lewy bodies in Parkinson′s disease (PD).
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
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