Manufactured for Sigma by Boston Biochem., Inc.
Ubiquitin-Carrier Protein H5c human may be used to study ubiquitin-proteasome system and its role in pathogenesis of human diseases.
Mediates the degradation of a myriad of short-lived regulatory proteins including the tumor suppressor p53 in the presence of E6/E6-AP or MDM2, the c-Fos transcription factor, and the signal-induced ubiquitination of IκBα, UBC5 is an essential gene in yeast.
Ubiquitin-Carrier Protein H5c human also referred to as UbcH5c is a recombinant protein that interacts with ZIPK and stimulate its ubiquitination and hence facilitates in regulating ZIPK accumulation in promyelocytic leukemia protein nuclear body (PML-NBs).
Solution in 50 mM HEPES, pH 7.6, 50 mM NaCl, 1 mM DTT in 10% glycerol.