U9257

Sigma-Aldrich

UbcH9 Conjugating Enzyme human

≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

MDL number:
NACRES:
NA.56

Quality Level

recombinant

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... UBE2E3(10477), UBE2I(7329)

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General description

Manufactured for Sigma by Boston Biochem., Inc.

Biochem/physiol Actions

UbcH9 mediates the conjugation of SUMO-1, SUMO-2, and SUMO-3 to a diverse variety of proteins without the help of an E3 ligase. This E2 conjugating enzyme interacts directly with protein substrates that are modified by SUMOylation, and may help in substrate recognition. UbcH9 is specific for the conjugation of proteins modified by SUMOylation.

Physical form

Solution in 50 mM HEPES, pH 7.5, 100 mM NaCl, 10 % glycerol, 1mM TCEP.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
J M Desterro et al.
FEBS letters, 417(3), 297-300 (1997-12-31)
Ubiquitin conjugating enzymes participate in the thioester cascade that leads to protein ubiquitination. Although Ubc9 is homologous to E2 ubiquitin conjugating enzymes we have shown that it is unable to form a thioester with ubiquitin, but can form a thioester...

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