UC167

Oxidized Nifedipine

powder, ~95% (HPLC)

• Synonym(s): 2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester
• Empirical Formula (Hill Notation): C₁₇H₁₆N₂O₆
• CAS Number: 67035-22-7
• Molecular Weight: 344.32
• MDL number: MFCD00153847
• UNSPSC Code: 12161501
• PubChem Substance ID: 329827652
• NACRES: NA.77

Properties

• assay: ~95% (HPLC)
• form: powder
• color: yellow
• mp: 100-105 °C
• storage temp.: 2-8°C
• SMILES string: COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O
• InChI: 1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3
• InChI key: UMQHJQGNGLQJPF-UHFFFAOYSA-N

Description

Application

Oxidized Nifedipine may be used:

• to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)[1]
• as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes[2]
• in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)[3]

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons[4].

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Nifedipine is a dihydropyridine derivative[5] and a calcium channel blocker.[6] It is used in treating hypertension and angina pectoris.[5] Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light.[6] The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H318
• pcodes: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves