V0377

[Arg⁸]-Vasopressin solution

Grade VI (synthetic), ~100 IU/mL in 0.9% NaCl

• Synonym(s): β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin
• Empirical Formula (Hill Notation): C₄₆H₆₅N₁₅O₁₂S₂
• CAS Number: 113-79-1
• Molecular Weight: 1084.23
• MDL number: MFCD00076738
• PubChem Substance ID: 24900692
• NACRES: NA.32

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• sterility: non-sterile
• type: Grade VI (synthetic)
• form: liquid
• contains: 0.4% 4-chlorobutanol as preservative
• concentration: ~100 IU/mL in 0.9% NaCl
• pH: ~3.5
• UniProt accession no.: P01185
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O
• InChI: 1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)
• InChI key: KBZOIRJILGZLEJ-UHFFFAOYSA-N
• Gene Information: human ... AVP(551)

Description

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Arg⁸]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.

Packaging

100, 1000, 50, 500 IU

Biochem/physiol Actions

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg⁸-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).

[Arg⁸]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point(F): 235.4 °F - closed cup
• Flash Point(C): 113 °C - closed cup