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V116

Sigma-Aldrich

Z-VAD-FMK

solid

Synonym(s):
N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
Empirical Formula (Hill Notation):
C22H30FN3O7
CAS Number:
Molecular Weight:
467.49
MDL number:
NACRES:
NA.77

biological source

synthetic

Quality Level

Assay

≥98% (TLC)

form

solid

color

white

solubility

DMSO: 20 mg/mL
H2O: insoluble

storage temp.

−20°C

InChI

1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

InChI key

MIFGOLAMNLSLGH-QOKNQOGYSA-N

Gene Information

human ... CASP3(836)
mouse ... CASP3(12367)
rat ... CASP3(25402)

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This Item
860700470597370940
Sigma-Aldrich

Sigma-Aldrich

V116

Z-VAD-FMK

Z-Ser-OH ≥99%

Sigma-Aldrich

860700

Z-Ser-OH

Z-Tyr-OH 97%

Sigma-Aldrich

470597

Z-Tyr-OH

Z-Aib-OH technical grade

Sigma-Aldrich

370940

Z-Aib-OH

assay

≥98% (TLC)

assay

≥99%

assay

97%

assay

-

form

solid

form

crystals

form

-

form

solid

color

white

color

-

color

-

color

-

solubility

DMSO: 20 mg/mL, H2O: insoluble

solubility

-

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

General description

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase). It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.

Application

Z-VAD-FMK has been used:
  • to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells
  • to induce autophagy in Jurkat and K562 cells
  • to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines
  • as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Caution

Hygroscopic

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

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