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Vitamin B12


α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, Cyanocobalamin
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
EC Number:
PubChem Substance ID:

Quality Level

biological source

synthetic (organic)






HPLC: suitable


red to brown

storage temp.


SMILES string




InChI key


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Vitamin B12 has been used:
  • as a constituent in vitamin mix solution in in vitro gut simulator
  • as a standard in size exclusion inductively coupled plasma mass spectroscopy (SEC-ICP-MS)
  • as a constituent of simulated plasma protein mixture for Raman spectra analysis
  • in surface plasmon resonance (SPR) analysis
  • as a medium supplement in neonatal rat ventricular myocytes (NRVM)


1, 5, 25 g in glass bottle
100, 250, 500 mg in glass bottle

Biochem/physiol Actions

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

Storage Class Code

11 - Combustible Solids



Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. How should I store a solution of Vitamin B12, Product V2876?

    Serum Vitamin B12 is highly unstable and should be protected from light and kept frozen. Cyanocobalamin is often used to supplement media. It has a maximal stability at pH = 7, but is photolysed to hydroxocobalamin with a zero-order rate constant.

  6. Vitamin B12, Product V2876, is produced by fermentation.  What bacteria is used to produce this product?

    The bacterial source for this product is considered proprietary.

  7. What can I use to make a solution of Vitamin B12, Product V2876?

    The specification sheet for Product V2876 (available from the product page on the website) indicates that the product is soluble in water (50 mg/mL), yielding a dark red solution.

  8. What is the Extinction Coefficient for Vitamin B12, Product V2876?

    Extinction Coefficient: E1% = 64 (550 nm), 204 (361 nm), 115 (278 nm) in water.  Extinction Coefficient: EmM = 27.5 (361 nm) in water.

  9. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Recombinant human collagen-based microspheres mitigate cardiac conduction slowing induced by adipose tissue-derived stromal cells
Smit NW, et al.
PLoS ONE, 12(8), e0183481-e0183481 (2017)
Raman spectroscopic analysis of high molecular weight proteins in solution-considerations for sample analysis and data pre-processing
Parachalil DR, et al.
Analyst, 143(24), 5987-5998 (2018)
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
Koh A, et al.
Cell, 175(4), 947-961 (2018)
A missense mutation in TCN2 is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin
Li P, et al.
Oncotarget, 8(33), 55216-55216 (2017)
Speciation of zinc in fish feed by size exclusion chromatography coupled to inductively coupled plasma mass spectrometry-Using fractional factorial design for method optimization and mild extraction conditions
Silva MS, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1104, 262-268 (2018)

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