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V4512

Sigma-Aldrich

Vascular Endothelial Growth Factor from mouse

VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym(s):
mVEGF, VEGF
MDL number:
NACRES:
NA.77

biological source

mouse

Quality Level

recombinant

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

powder

potency

≤10 ng/mL

quality

endotoxin tested

mol wt

protein 39 kDa

packaging

pkg of 10 μg
pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

<1 EU/μg

UniProt accession no.

storage temp.

−20°C

Gene Information

mouse ... VEGFA(22339)

General description

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.

Application

Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).

Other Notes

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.

Analysis Note

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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SDS

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