V4758

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse

Name: Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse
Brand: SIGMA
Price: 1090 USD
Availability: InStock

clone 26503, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-VEGF

Slide 1 of 1

Select a Size

0.5 MG

$1,090.00

Available to ship TODAYDetails

A recombinant, preservative-free antibody is available for your target. Try ZRB1320

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00282511

Key Documents

View All Documentation

Product Name

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse, clone 26503, purified immunoglobulin, lyophilized powder

Quality Level

200

Gene Information

human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

26503, monoclonal

form

lyophilized powder

species reactivity

primate, human

technique(s)

capture ELISA: 2-8 μg/mL
neutralization: suitable
western blot: 1 μg/mL

isotype

IgG2b

UniProt accession no.

P15692

storage temp.

−20°C

target post-translational modification

unmodified

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	V1253	SAB1402390	SAB1406581
Sigma-Aldrich V4758 Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse	Sigma-Aldrich V1253 Anti-Vascular Endothelial Growth Factor antibody produced in goat	Sigma-Aldrich SAB1402390 Monoclonal Anti-VEGF antibody produced in mouse	Sigma-Aldrich SAB1406581 Anti-VEGFB antibody produced in mouse
biological source mouse	biological source goat	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)	Gene Information mouse ... Vegfa(22339)	Gene Information human ... VEGFA(7422)	Gene Information human ... VEGFB(7423)
clone 26503, monoclonal	clone polyclonal	clone 3F7, monoclonal	clone polyclonal
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity primate, human	species reactivity mouse	species reactivity human	species reactivity human

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse was used to block the interaction between VEGF and kinase domain receptor in Calf Pulmonary Aortic Endothelial (CPAE) cells.

Biochem/physiol Actions

The vascular endothelial growth factor family consists of five members, VEGF-A to VEGF-E. They play important roles in important role in embryonic vasculogenesis, angiogenesis and homeostasis. The interaction between VEGFs and their respective receptors results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

The antibody will neutralize the biological activity of recombinant human VEGF₁₆₅. It also recognizes VEGF₁₂₁.

Immunogen

purified recombinant Sf21-derived human VEGF (165 aa isoform).

Physical form

Lyophilized from 0.2 um-filtered solution in PBS, pH 7.4 with 5% Trehalose.

Not finding the right product?

Try our Product Selector Tool.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Intracellular virion traffic to the endosome driven by cell type specific sialic acid receptors determines parvovirus tropism.

Tania Calvo-López et al.

Frontiers in microbiology, 13, 1063706-1063706 (2023-02-10)

Parvoviruses are promising anticancer and gene therapy agents, but a deep knowledge of the entry process is crucial to exploit their therapeutic potential. We addressed this issue while attempting to retarget the oncolytic parvovirus minute virus of mice (MVMp) to

VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells.

A Ohwada et al.

Thorax, 58(4), 328-332 (2003-04-02)

Acid induced pneumonitis resulting in acute respiratory distress syndrome (ARDS) is characterised by increased alveolar permeability and accumulation of neutrophils. It is hypothesised that vascular endothelial growth factor (VEGF) is involved in the development of lung oedema. Furthermore, lower levels

Antiangiogenic Vascular Endothelial Growth Factor-Blocking Peptides Displayed on the Capsid of an Infectious Oncolytic Parvovirus: Assembly and Immune Interactions.

Esther Grueso et al.

Journal of virology, 93(19) (2019-07-19)

As many tumor cells synthetize vascular endothelial growth factors (VEGF) that promote neo-vascularization and metastasis, frontline cancer therapies often administer anti-VEGF (α-VEGF) antibodies. To target the oncolytic parvovirus minute virus of mice (MVM) to the tumor vasculature, we studied the

Selective binding of C-6 OH sulfated hyaluronic acid to the angiogenic isoform of VEGF(165).

Dong-Kwon Lim et al.

Biomaterials, 77, 130-138 (2015-11-21)

Vascular endothelial growth factor 165 (VEGF165) is an important extracellular protein involved in pathological angiogenesis in diseases such as cancer, wet age-related macular degeneration (wet-AMD) and retinitis pigmentosa. VEGF165 exists in two different isoforms: the angiogenic VEGF165a, and the anti-angiogenic

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis.

R Binétruy-Tournaire et al.

The EMBO journal, 19(7), 1525-1533 (2000-04-04)

Vascular endothelial growth factor (VEGF) binding to the kinase domain receptor (KDR/FLK1 or VEGFR-2) mediates vascularization and tumor-induced angiogenesis. Since there is evidence that KDR plays an important role in tumor angiogenesis, we sought to identify peptides able to block

View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service