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V6879

Sigma-Aldrich

[Lys8]-Vasopressin

≥98% (HPLC)

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Synonym(s):
Lysine vasopressin, Lyspressin
Empirical Formula (Hill Notation):
C46H65N13O12S2
CAS Number:
Molecular Weight:
1056.22
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.32

biological source

synthetic (organic)

sterility

non-sterile

Assay

≥98% (HPLC)

form

powder

solubility

0.1 M acetic acid: 20 mg/mL, clear, colorless

UniProt accession no.

shipped in

ambient

storage temp.

−20°C

SMILES string

CC(O)=O.NCCCCC(NC(=O)C1CCCN1C(=O)C2CSSCC(N)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(Cc4ccccc4)C(=O)NC(CCC(N)=O)C(=O)NC(CC(N)=O)C(=O)N2)C(=O)NCC(N)=O

InChI

1S/C46H65N13O12S2.C2H4O2/c47-17-5-4-9-29(40(65)52-22-38(51)63)54-45(70)35-10-6-18-59(35)46(71)34-24-73-72-23-28(48)39(64)55-31(20-26-11-13-27(60)14-12-26)43(68)56-32(19-25-7-2-1-3-8-25)42(67)53-30(15-16-36(49)61)41(66)57-33(21-37(50)62)44(69)58-34;1-2(3)4/h1-3,7-8,11-14,28-35,60H,4-6,9-10,15-24,47-48H2,(H2,49,61)(H2,50,62)(H2,51,63)(H,52,65)(H,53,67)(H,54,70)(H,55,64)(H,56,68)(H,57,66)(H,58,69);1H3,(H,3,4)

InChI key

NKWAIKZITYLOMT-UHFFFAOYSA-N

Gene Information

human ... AVP(551)

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This Item
V2013V1005V4253
[Lys8]-Vasopressin ≥98% (HPLC)

Sigma-Aldrich

V6879

[Lys8]-Vasopressin

assay

≥98% (HPLC)

assay

≥95%

assay

≥95% (HPLC)

assay

≥97% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

0.1 M acetic acid: 20 mg/mL, clear, colorless

solubility

50% acetic acid: soluble 1 mg/mL, clear, colorless

solubility

H2O: soluble 20 mg/mL, clear, colorless

solubility

water: 1 mg/mL, clear, colorless

UniProt accession no.

P01185

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

shipped in

ambient

shipped in

ambient

shipped in

ambient

shipped in

ambient

Amino Acid Sequence

Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 [Disulfide Bridge: 1-6]

Application

[Lys8]-Vasopressin was used as a test compound in quantitative analysis of peptides and proteins by using on-line capillary isoelectric focusing-mass spectrometry.The product was used for studying the coupling of a polymer-based microchip electrophoresis to MALDI-TOF MS by using rotating ball interface.

Biochem/physiol Actions

Predominant form of vasopressin present in pigs and marsupials. It has lower vasopressor and antidiuretic activity than Arg8-vasopressin.
[Lys8]-Vasopressin also refers as Lysine vasopressin or Lyspressin is the predominant form of vasopressin present in pigs and marsupials. It antagonizes the amnesia in rats. Lyspressin can also induce resistance to extinction of active avoidance behaviour.

Preparation Note

2 mg of [Lys8]-Vasopressin dissolves in 0.1 mL, 0.1M HOAc to yield a clear, colorless solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Brain, behavior and evolution, 33(4), 193-204 (1989-01-01)
The present study describes the topography of immunoreactive (ir) oxytocin (OXY) and vasopressin (AVP) neurons in the forebrain of Equus caballus and the coexistence of ir proopiomelanocortin (POMC)-derived peptides in the same cells. These data are compared to those for
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Current drug metabolism, 14(2), 186-192 (2013-02-27)
Vasopressin and its analogue terlipressin are potent vasopressors which have been recently proposed in the treatment of catecholamine-resistant septic shock. We review the physiology, metabolism and pharmacology of vasopressin and terlipressin, as well as the available data on their efficacy
Mads Egerod Israelsen et al.
Ugeskrift for laeger, 175(22), 1562-1566 (2013-06-01)
Cirrhosis, ascites and renal impairment are associated with high morbidity and mortality. The hepatorenal syndrome (HRS) is a type of renal failure that affects patients with cirrhosis and ascites. This paper provides an update on evidence-based interventions in HRS. A
Matthias Hinz et al.
Annals of hepatology, 12(1), 92-99 (2013-01-08)
Combination therapy with terlipressin and albumin substitution is considered a widely accepted treatment regimen for patients with hepatorenal syndrome (HRS). However, only half of the patients respond to treatment and to date albumin substitution and terlipressin therapy are among the
Harrison K Musyimi et al.
Electrophoresis, 26(24), 4703-4710 (2005-12-17)
We report on the coupling of a polymer-based microfluidic chip to a MALDI-TOF MS using a rotating ball interface. The microfluidic chips were fabricated by micromilling a mold insert into a brass plate, which was then used for replicating polymer

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