WH0005534M1

Monoclonal Anti-PPP3R1 antibody produced in mouse

Name: Monoclonal Anti-PPP3R1 antibody produced in mouse
Brand: SIGMA
Price: 580 USD

clone 4E1, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-CALNB1, Anti-CNB, Anti-CNB1, Anti-protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)

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100 μG

$580.00

Ships within 2 weeks. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00282169

Key Documents

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Product Name

Monoclonal Anti-PPP3R1 antibody produced in mouse, clone 4E1, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4E1, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL

isotype

IgGλ

GenBank accession no.

BC027913

UniProt accession no.

P63098

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... PPP3R1(5534)

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Show Differences

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This Item	WH0005530M3	SAB1409493	WH0094274M1
Sigma-Aldrich WH0005534M1 Monoclonal Anti-PPP3R1 antibody produced in mouse	Sigma-Aldrich WH0005530M3 Monoclonal Anti-PPP3CA antibody produced in mouse	Sigma-Aldrich SAB1409493 Monoclonal Anti-PPP3CC antibody produced in mouse	Sigma-Aldrich WH0094274M1 Monoclonal Anti-PPP1R14A antibody produced in mouse
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... PPP3R1(5534)	Gene Information human ... PPP3CA(5530)	Gene Information human ... PPP3CC(5533)	Gene Information human ... PPP1R14A(94274)
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
clone 4E1, monoclonal	clone 2G8, monoclonal	clone 4D1, monoclonal	clone 3A7, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human	species reactivity human	species reactivity human	species reactivity human

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

PPP3R1 (AAH27913, 1 a.a. ~ 170 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVIDIFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMVGNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV

Physical form

Solution in phosphate buffered saline, pH 7.4

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number

07082-4E1

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Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer.

Liyun Luo et al.

Nature communications, 12(1), 2699-2699 (2021-05-13)

Resistance to Herceptin represents a significant challenge for successful treatment of HER2-positive breast cancer. Here, we show that in Herceptin-sensitive cells, FOXO3a regulates specific miRNAs to control IGF2 and IRS1 expression, retaining basic IGF2/IGF-1R/IRS1 signaling. The basic activity maintains expression

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