X0626

Xanthine

≥99.5% (HPLC), purified by recrystallization

• Synonym(s): 2,6-Dihydroxypurine
• Empirical Formula (Hill Notation): C₅H₄N₄O₂
• CAS Number: 69-89-6
• Molecular Weight: 152.11
• Beilstein: 8733
• EC Number: 200-718-6
• MDL number: MFCD00078453
• PubChem Substance ID: 24902122
• NACRES: NA.51

Properties

• Quality Level: 400
• assay: ≥99.5% (HPLC)
• purified by: recrystallization
• solubility: 1 M NaOH: soluble 50 mg/mL, clear, colorless to faintly yellow
• SMILES string: O=C1NC(=O)c2nc[nH]c2N1
• InChI: 1S/C5H4N4O2/c10-4-2-3(7-1-6-2)8-5(11)9-4/h1H,(H3,6,7,8,9,10,11)
• InChI key: LRFVTYWOQMYALW-UHFFFAOYSA-N

Description

General description

Natural sources of xanthine or its derivatives include animal organs, yeast, potatoes, coffee beans, and tea. Xanthine is a purine that is produced from several different precursors in the purine metabolic pathway: deamination of guanine-by-guanine deaminase and conversion of hypoxanthine by xanthine oxidoreductase.

Application

Xanthine has been used in the measurement of the activity of superoxide dismutase by the xanthine-oxidase-cytochrome c reduction method.[1][2] It has also been used as a substrate for the measurement of xanthine oxidase activity[3] in different types of milk[4]

Packaging

5, 10, 25 g in poly bottle

Biochem/physiol Actions

Xanthine and xanthine oxidase are used to generate superoxide radicals to measure the activity of superoxide dismutase. Xanthine is a precursor metabolite to uric acid in purine metabolism. It has been noted as a biomarker of conditions such as gout.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves