Y102

YC-1

powder

• Synonym(s): 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole
• Empirical Formula (Hill Notation): C₁₉H₁₆N₂O₂
• CAS Number: 170632-47-0
• Molecular Weight: 304.34
• MDL number: MFCD06407798
• PubChem Substance ID: 24278782
• NACRES: NA.77

Properties

• form: powder
• Quality Level: 200
• color: white to yellow
• solubility: DMSO: 10 mg/mL; H₂O: insoluble
• SMILES string: OCc1ccc(o1)-c2nn(Cc3ccccc3)c4ccccc24
• InChI: 1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
• InChI key: OQQVFCKUDYMWGV-UHFFFAOYSA-N
• Gene Information: human ... PDE5A(8654)

Description

Application

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:

• to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
• to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
• to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.

Biochem/physiol Actions

NO (nitric oxide)-independent activator of soluble guanylyl cyclase.

YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves