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Z0127

Zatebradine hydrochloride

≥98% (HPLC), HCN channel blocker, powder

Synonym(s):

7,8-Dimethoxy-3-[3-[-N-[2-(3,4 dimethoxyphenyl)ethyl]-N-methylamino]propyl]-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one hydrochloride, UL-FS49

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10 mg

Available to ship TODAYfromMILWAUKEE

$296.00
50 mg

Available to ship TODAYfromMILWAUKEE

$1,120.00
$952.00

About This Item

Empirical Formula (Hill Notation):
C26H37ClN2O5
CAS Number:
91940-87-3
Molecular Weight:
493.04
UNSPSC Code:
12352200
PubChem Substance ID:
24724672
NACRES:
NA.77
MDL number:
MFCD06798356
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated

$296.00

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Product Name

Zatebradine hydrochloride, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >10 mg/mL

originator

Boehringer Ingelheim

storage temp.

2-8°C

SMILES string

Cl[H].COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC

InChI

1S/C26H36N2O5.ClH/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29;/h7-8,15-17H,6,9-14,18H2,1-5H3;1H

InChI key

ZRNKXJHEQKMWCH-UHFFFAOYSA-N

Application

Zatebradine hydrochloride has been used:
  • as an If blocker to study its effects on cardiomyocyte clusters (CMCs)
  • as a hyperpolarization-activated and cyclic nucleotide-gated (HCN) channel inhibitor to study its effects on viability of degenerating rod or cone photoreceptors in mice
  • as a bradycardiac agent to study its effects on tachycardia and elevated temperature in fish

Biochem/physiol Actions

HCN channel blocker: blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels.
Zatebradine is a bradycardiac agent.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
SML0281SML0893SML0556
Zatebradine hydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

Z0127

Zatebradine hydrochloride

Ivabradine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0281

Ivabradine hydrochloride

M8-B hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0893

M8-B hydrochloride

LY344864 hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML0556

LY344864 hydrochloride

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: >10 mg/mL

solubility

H2O: ≥5 mg/mL (warmed)

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

H2O: 10 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

storage condition

desiccated

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000223498
0000223496
0000223498
0000223496
0000157677

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Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Effects of zatebradine and propranolol on canine ischemia and reperfusion-induced arrhythmias
Naito H, et al.
European Journal of Pharmacology, 388(2), 171-176 (2000)
Christopher M Wilson et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 164(1), 258-263 (2012-09-27)
Pharmacological ion-channel blockers were used to investigate the spontaneous heart rates in Pacific hagfish, Eptatretus stoutii. Zatebradine, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, vastly reduced atrial and ventricular contraction rates in a similar concentration-dependent manner, indicating a major role
Hiroko Izumi-Nakaseko et al.
Journal of pharmacological sciences, 135(1), 44-50 (2017-09-21)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been used in many studies to assess proarrhythmic risks of chemical compounds. In those studies, field potential durations (FPD) of hiPSC-CMs have been corrected by clinically used Fridericia's and/or Bazett's formulae, however
View All Related Papers

Global Trade Item Number

SKUGTIN
Z0127-50MG04061832577838
Z0127-10MG04061832577821

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