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Z2626

Sigma-Aldrich

Zaragozic acid A trisodium salt

≥95% (HPLC), microbial

Synonym(s):
L-694,599, Squalestatin
Empirical Formula (Hill Notation):
C35H43O14Na3
CAS Number:
Molecular Weight:
756.68
MDL number:
NACRES:
NA.77

biological source

microbial

Quality Level

assay

≥95% (HPLC)

form

lyophilized powder

solubility

DMSO: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

shipped in

wet ice

storage temp.

−20°C

Application

Zaragozic acid A trisodium salt has been used as:
  • a component of serum-free medium for human embryonic kidney cells in a wound scratch assay to test its effect on wound healing
  • a farnesyl-diphosphate farnesyltransferase 1 (FDFT1) or squalene synthase inhibitor in stromal cells
  • a cholesterol synthesis inhibitor in T cells

Biochem/physiol Actions

Potent inhibitor, in vivo and in vitro, of mammalian, fungal and Saccharomyces cervisiae squalene synthase. Squalene synthase is the first committed enzyme in sterol synthesis, catalyzing the reductive condensation of farnesyl pyrophosphate to form squalene. As a squalene synthase inhibitor, zaragozic acid produces lower plasma cholesterol levels in primates. Treatment of rats with zaragozic acid A caused an increase in hepatic low density lipoprotein (LDL) receptor mRNA levels.

Legal Information

Manufactured and sold under a restricted license from Merck & Co., Inc., Kenilworth, NJ, U.S.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

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Certificate of Origin

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