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Z4250

Sigma-Aldrich

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

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Synonym(s):
Yeast Cell Wall
CAS Number:
MDL number:

biological source

Saccharomyces cerevisiae

Quality Level

form

powder with small lumps

technique(s)

flow cytometry: suitable
tissue culture: suitable

color

off-white to light brown

storage temp.

2-8°C

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This Item
C2436YSC1YBD
Yeast Brewers Debittered, inactive

Sigma-Aldrich

YBD

Yeast Brewers

form

powder with small lumps

form

powder

form

powder or solid

form

powder

technique(s)

flow cytometry: suitable, tissue culture: suitable

technique(s)

-

technique(s)

-

technique(s)

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

color

off-white to light brown

color

-

color

-

color

-

Application

  • in flow cytometry
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade
  • for respiratory burst (RB) assay
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium
  • to induce thermal hyperalgesia in mice

Biochem/physiol Actions

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

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