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MilliporeSigma

Z4250

Sigma-Aldrich

Zymosan A from Saccharomyces cerevisiae

for inducing inflamatory response

Synonym(s):

Yeast Cell Wall

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250 MG
$69.80
1 G
$213.00
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$887.00

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250 MG
$69.80
1 G
$213.00
5 G
$887.00

About This Item

CAS Number:
58856-93-2
MDL number:
MFCD00082157
UNSPSC Code:
12352202
NACRES:
NA.61

Key Documents

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$69.80

In StockDetails

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biological source

Saccharomyces cerevisiae

Quality Level

200

form

powder with small lumps

technique(s)

flow cytometry: suitable
tissue culture: suitable

color

off-white to light brown

storage temp.

2-8°C

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This Item
YSC2YSC1Y1000
Zymosan A from Saccharomyces cerevisiae for inducing inflamatory response

Z4250

Zymosan A from Saccharomyces cerevisiae

Yeast from Saccharomyces cerevisiae Type II

YSC2

Yeast from Saccharomyces cerevisiae

Yeast from Saccharomyces cerevisiae Type I

YSC1

Yeast from Saccharomyces cerevisiae

Select Yeast Extract powder, BioReagent, suitable for cell culture, suitable for insect cell culture

Y1000

Select Yeast Extract

technique(s)

flow cytometry: suitable, tissue culture: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

Saccharomyces cerevisiae

biological source

-

form

powder with small lumps

form

powder or solid

form

powder or solid

form

powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

color

off-white to light brown

color

-

color

-

color

-

Application

  • in flow cytometry[1]
  • to study its effect on head kidney leukocytes from rainbow trout (Oncorhynchus mykiss)[2]

Zymosan A from Saccharomyces cerevisiae has been used:
  • as a positive control to determine the activation of complement cascade[3]
  • for respiratory burst (RB) assay[4]
  • to assess its effects on performance, immunity, heat shock protein and apoptosis related gene expressions of dairy cows under heat stress (HS)[5]
  • a stimulating agent in Krebs-Ringer phosphate (KRP) medium[6]
  • to induce thermal hyperalgesia in mice[7]

Biochem/physiol Actions

Zymosan is prepared from yeast cell wall and consists of protein-carbohydrate complexes. It is used to induce experimental sterile inflammation. In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation. Zymosan A also raises cyclin D2 levels suggesting a role for the latter in macrophage activation besides proliferation. It potentiates acute liver damage after galactosamine injection suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action. Zymosan A, a 13 beta glucan contributes to the development of organic dust-induced respiratory disease.[8]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7622
BCCL0988
BCCJ4416
BCCG7848
BCCF4922

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Questions

1–9 of 9 Questions  

  1. How can I solubilize Zymosan? The information sheet does not provide this information. Can it be dissolved in water?

    1 answer

    1. This product is soluble in organic solvents as follows:
      - Chloroform: 100 µg/ml
      - Dimethyl sulfoxide: 200 µg/ml
      - Ethanol: 100 µg/ml.

      According to the 'Solubility/Solution Stability' section in the product information sheet, this product is not soluble in water but can be suspended uniformly in saline solution.

      Helpful?

  2. Is Z4250, Zymosan A from Saccharomyces cerevisiae, soluble in DMSO?

    1 answer

    1. Yes, this item is soluble in the following solvents:
      - Chloroform: 100 µg/ml
      - DMSO: 200 µg/ml
      - Ethanol: 100 µg/ml

      Helpful?

  3. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  4. What is the particle size of Product Z4250, Zymosan?

    1 answer

    1. Sigma-Aldrich does not measure the particle size of zymosan. The average diameter of zymosan particles has been reported to be about 3 μm, as described on the product information sheet (under Documents, above), with the cited reference.

      Helpful?

  5. How can Product Z4250, Zymosan be prepared for use in a properdin assay?

    1 answer

    1. Information on preparation of zymosan for use in a properdin assay, which includes boiling zymosan suspensions, is described on the product information sheet (under Documents, above).

      Helpful?

  6. Can Product Z4250, Zymosan suspension be autoclaved?

    1 answer

    1. We have no information as to whether zymosan suspensions can be autoclaved.  However, suspensions are stable to boiling conditions.

      Helpful?

  7. What is the appearance of Product Z4250, Zymosan?

    1 answer

    1. The product is a powder which is described on the specification sheet.

      Helpful?

  8. What is the source of the Zymosan in Product Z4250?

    1 answer

    1. This zymosan is prepared from single cell yeast.

      Helpful?

  9. How can I solubilize Zymosan, Product Z4250?

    1 answer

    1. Solubility information can be found in the product information sheet (under Documents, above) on our website.

      Helpful?

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