14023AST

Astec^® CHIROBIOTIC^® TAG Chiral (5 μm) HPLC Columns

Name: Astec<SUP>&#174;</SUP> CHIROBIOTIC<SUP>&#174;</SUP> TAG Chiral (5 μm) HPLC Columns
Brand: SUPELCO
Price: 3200 USD
Availability: InStock

L × I.D. 15 cm × 4.6 mm, HPLC Column

Synonym(s):

Chirobiotic TAG Chiral Chromatography Column

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1 EA

$3,200.00

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About This Item

UNSPSC Code:

41115700

eCl@ss:

32110501

NACRES:

SB.52

L × i.d.:

15 cm × 4.6 mm

Particle size:

5 μm

Matrix active group:

teicoplanin aglycone phase

Pore size:

100 Å

Matrix:

High-purity silica gel particle platform, fully porous particle

Key Documents

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Product Name

Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

material

stainless steel column

agency

suitable for USP L63

description

HPLC column

product line

Astec^®

packaging

pkg of 1 ea

manufacturer/tradename

Astec^®

parameter

0-45 °C temperature, 241 bar pressure (3500 psi)

technique(s)

HPLC: suitable, LC/MS: suitable

L × I.D.

15 cm × 4.6 mm

matrix

High-purity silica gel particle platform, fully porous particle

matrix active group

teicoplanin aglycone phase

particle size

5 μm

pore size

100 Å

operating pH range

3.0-6.8

separation technique

chiral

Quality Level

100

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This Item	14018AST	14019AST	14020AST
Supelco 14023AST Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column	Supelco 14018AST Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column	Supelco 14019AST Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column	Supelco 14020AST Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column
particle size 5 μm	particle size 5 μm	particle size 5 μm	particle size 5 μm
matrix active group teicoplanin aglycone phase	matrix active group teicoplanin aglycone phase	matrix active group teicoplanin aglycone phase	matrix active group teicoplanin aglycone phase
separation technique chiral	separation technique chiral	separation technique chiral	separation technique chiral
L × I.D. 15 cm × 4.6 mm	L × I.D. 10 cm × 2.1 mm	L × I.D. 15 cm × 2.1 mm	L × I.D. 25 cm × 2.1 mm
pore size 100 Å	pore size 100 Å	pore size 100 Å	pore size 100 Å
agency suitable for USP L63	agency suitable for USP L63	agency suitable for USP L63	agency suitable for USP L63

General description

The removal of three carbohydrate moieties gives CHIROBIOTIC^® TAG complementary selectivity to CHIROBIOTIC^® T. Resolution is enhanced toward many of the amino acids, α, β, γ and cyclic, and especially sulfur-containing methionine, histidine and cysteine. A number of neutral molecules like the oxazolidinones, hydantoins and diazepines have shown enhanced resolution and, more remarkably, in the single solvents like methanol, ethanol and acetonitrile. Some acidic molecules have also shown increased selectivity.

Bonded phase: Teicoplanin aglycone
Operating pH range: 3.0 - 6.8
Particle diameter: 5, 10 or 16 μm
Pore size: 100 Å

Application

High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This study emphasizes the effectiveness of the Astec^® CHIROBIOTIC^® TAG Chiral HPLC Column in the enantioseparation of complex cyclic amino acids. The methodology detailed provides profound insights into the chirality aspects of biochemical molecules, which is crucial for the synthesis of novel pharmaceutical agents and the study of biochemical pathways. This research supports analytical chemists in academia focused on developing chiral analytical methods and advancing chemical synthesis (Berkecz et al., 2009).

Other Notes

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany

CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

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Enantio- and chemo-selective HPLC separations by chiral-achiral tandem-columns approach: the combination of CHIROBIOTIC TAG and SCX columns for the analysis of propionyl carnitine and related impurities.

Ilaria D'Acquarica et al.

Journal of chromatography. A, 1061(2), 167-173 (2005-01-12)

We describe a new tandem-columns chiral-achiral HPLC arrangement by using a chiral column (CHIROBIOTIC TAG) connected in series with an achiral column (Spherisorb S5 SCX), based on a strong cationic exchange mechanism; this approach is very useful for the analysis

Adsorption behavior of a teicoplanin aglycone bonded stationary phase under harsh overload conditions

Bechtold, Matthias, et al.

Journal of Chromatography A, 1154 (1-2), 2477-2286 (2007)

A direct HPLC method for the resolution and quantitation of the R-(-)- and S-(+)-enantiomers of vigabatrin (gamma-vinyl-GABA) in pharmaceutical dosage forms using teicoplanin aglycone chiral stationary phase.

Abdulrahman A Al-Majed

Journal of pharmaceutical and biomedical analysis, 50(1), 96-99 (2009-05-19)

A direct chiral high-performance liquid chromatography (HPLC) method was developed and validated for the resolution and quantification of antiepileptic drug enantiomers, R-(-)- and S-(+)-vigabatrin (gamma-vinyl-gamma-aminobutyric acid) in pharmaceutical products. The separation was optimized on a macrocyclic glycopeptide antibiotic chiral stationary

Simulated moving bed enantioseparation of amino acids employing memory effect-constrained chromatography columns.

Markus Fuereder et al.

Journal of chromatography. A, 1236, 123-131 (2012-04-03)

Teicoplanin aglycone-based chromatography columns (Chirobiotic TAG) enable amino acid enantioseparation with aqueous mobile phases, which perfectly accommodates the distinct hydrophilicity of most amino acids. Therefore, this stationary phase constitutes a promising option in particular for preparative-scale separations that require high

Enantiorecognition of triiodothyronine and thyroxine enantiomers using different chiral selectors by HPLC and micro-HPLC.

Julia Koidl et al.

Journal of biochemical and biophysical methods, 70(6), 1254-1260 (2007-11-06)

This paper deals with the chiral separation of triiodothyronine (T3) and thyroxine (T4) by HPLC and micro-HPLC. The separation of T3 and T4 is of great pharmaceutical and clinical interest, since the enantiomers exhibit different pharmacological activities. The HPLC measurements

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Astec® CHIROBIOTIC® TAG Chiral (5 μm) HPLC Columns