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47865-U

Nicotinamide (Niacinamide)

analytical standard

Synonym(s):

Nicotinamide, NAM, NIC, Niacinamide, Nicotinic acid amide, Pyridine-3-carboxylic acid amide, Vitamin B3, Vitamin PP

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About This Item

Empirical Formula (Hill Notation):
C6H6N2O
CAS Number:
98-92-0
Molecular Weight:
122.12
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
329757343
EC Number:
202-713-4
Beilstein/REAXYS Number:
383619
MDL number:
MFCD00006395

grade

analytical standard

CofA

current certificate can be downloaded

feature

standard type water soluble vitamin

packaging

ampule of 1000 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

128-131 °C (lit.)

application(s)

clinical testing

format

neat

storage temp.

2-30°C

SMILES string

NC(=O)c1cccnc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

Gene Information

human ... PARP1(142), SIRT2(22933)

General description

Nicotinamide (Niacinamide), belonging to the class of water-soluble B vitamins, is typically produced from nicotinic acid (vitamin B3). It is found as a component of food products. It has been suggested for the treatment of pellagra, psoriasis, schizophrenia, and type I diabetes. It also exhibits anti-inflammatory activity.[1]

Application

Nicotinamide (Niacinamide) may be used as a reference standard for the determination of the analyte in pharmaceutical formulations and biological fluids by chromatography, UV-visible spectrophotometry and multivariate analysis.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Nicotinamide is an amide derivative of vitamin B3 and a PARP inhibitor

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD9147
LRAD7518
LRAD5073
LRAC9819
LRAC6832

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Articles

Determination of vitamins B and preservatives

Learn to separate and quantify B vitamins and preservatives in capsules with HPLC-UV and Purospher® STAR RP-8 column. Validated for precision.

Industrial application of green chromatography?I. Separation and analysis of niacinamide in skincare creams using pure water as the mobile phase
Yang Y, et al.
Talanta, 84(1), 169-174 (2011)
Evaluation of analytical tools and multivariate methods for quantification of co-former crystals in ibuprofen-nicotinamide co-crystals
Soares FLF and Carneiro RL
Journal of Pharmaceutical and Biomedical Analysis, 89, 166-175 (2014)
Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction
Chatzimichalakis PF, et al.
Journal of Separation Science, 27(14), 1181-1188 (2004)
View All Related Papers

Global Trade Item Number

SKUGTIN
47865-U04061835559954

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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