Katerina Papezová et al.
Journal of chromatography. A, 1150(1-2), 327-331 (2006-10-03)
Substrate inhibition is a common phenomenon in enzyme kinetics. We report here for the first time its study by a combination of the electrophoretically mediated microanalysis (EMMA) methodology with a partial filling technique. In this setup, the part of capillary...
Annamaria Colacci et al.
Toxicology in vitro : an international journal published in association with BIBRA, 25(6), 1183-1190 (2011-06-16)
Cell transformation assays (CTAs) are currently regarded as the only possible in vitro alternative to animal testing for carcinogenesis studies. CTAs have been proposed as screening tests for the carcinogenic potential of compounds that have no evidence of genotoxicity but...
Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane.
Mutation research, 76(3), 269-295 (1980-11-01)
Elisabeth M Loecken et al.
Chemical research in toxicology, 21(2), 453-458 (2008-01-01)
The environmental contaminant 1,2-dibromoethane and diepoxybutane, an oxidation product of the important industrial chemical butadiene, are bis-functional electrophiles and are known to be mutagenic and carcinogenic. One mechanism by which bis-electrophiles can exert their toxic effects is through the induction...
Frida Jonsson et al.
Human mutation, 36(4), 463-473 (2015-02-14)
Corneal dystrophies are a clinically and genetically heterogeneous group of inherited disorders that bilaterally affect corneal transparency. They are defined according to the corneal layer affected and by their genetic cause. In this study, we identified a dominantly inherited epithelial...