All Photos(1)
material
polypropylene tube
product line
SupelMIP®
composition
bed wt., 25 mg
packaging
pk of 50
volume
3 mL
application(s)
food and beverages
General description
SupelMIP SPE phases were developed by MIP Technologies AB, which is one of the leading authorities and commercial pioneers of molecular imprinted polymers for process scale separations, analytical chromatography, and sample preparation.
The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.
By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.
Visit www.sigma-aldrich.com/supelmip to learn more.
The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.
By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.
Visit www.sigma-aldrich.com/supelmip to learn more.
Application
Developed for the class-selective extraction of Amphetamine, Methamphetamine, Phentermine, MDA, MDMA, MDEA from human urine.
The method is highly reproducible and offers an average recovery greater than 80%; and limits of detection in the range of 0.8 - 12.9 pg/mL from 1 mL of urine.
The method is highly reproducible and offers an average recovery greater than 80%; and limits of detection in the range of 0.8 - 12.9 pg/mL from 1 mL of urine.
Features and Benefits
- Highly selective SPE for trace analysis in complex matrices
- Achieve lower detection limits
- Significant time and cost savings
- Improved MS-compatibility
Legal Information
SupelMIP is a registered trademark of Sigma-Aldrich Co. LLC
Certificate of Analysis
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Certificate of Origin
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Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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