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54127-U

Supelco

2-(2-Pyridyl)ethyl Silica Gel

bed wt 100 mg, volume 1 mL, pk of 108

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NACRES:
NB.21

composition

bed wt, 100 mg

Quality Level

packaging

pk of 108

technique(s)

solid phase extraction (SPE): suitable

volume

1 mL

matrix active group

WAX phase

application(s)

food and beverages

separation technique

ion exchange

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This Item
1.0574553798552664-U
technique(s)

solid phase extraction (SPE): suitable

technique(s)

thin layer chromatography (TLC): suitable

technique(s)

-

technique(s)

solid phase extraction (SPE): suitable

matrix active group

WAX phase

matrix active group

-

matrix active group

-

matrix active group

ammonium ion, quaternary bonding, polymerically bonded, chloride counter-ion

application(s)

food and beverages

application(s)

-

application(s)

-

application(s)

food and beverages

composition

bed wt, 100 mg

composition

-

composition

-

composition

bed wt., 500 mg

volume

1 mL

volume

-

volume

-

volume

3 mL

General description

Retention Mechanism: Anion-exchange
Sample Matrix Compatibility: Organic or aqueous Solutions

  • Weak anion exchanger ideal for extracting strong basic compounds that remain charged at all pH levels
  • Unlike conventional weak anion exchange SPE phases such as -NH2 (aminopropyl) that have a pKa of 9-10, a pH ≤ 7 is required to protonate or ionize the stationary phase to facilitate analyte retention. Elution is typically done by increasing the pH to 11 resulting in neutralization of the SPE phase.
  • 2-(2-pyridyl)-ethyl silica gel has a pKa of ~6. Therefore, analyte elution is feasible at a pH ≥ 7. This characteristic is important for extracting analytes that are not stable (e.g. hydrolyzes) at high pHs typically required for elution when using traditional weak anion exchangers.
  • Ideal for extracting acyl-coenzyme A esters from tissue.
  • For more information, please see: Minkler, P.E., Kerner, J., Ingalls, S.T., Hoppel, C.L., Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue, Analytical Biochemistry 376 (2008) 275–276

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Andrea Arias-Alvarado et al.
Analytical biochemistry, 615, 114067-114067 (2020-12-20)
Cellular availability of acetyl-CoA, a central intermediate of metabolism, regulates histone acetylation. The impact of a high-fat diet (HFD) on the turnover rates of acetyl-CoA and acetylated histones is unknown. We developed a method for simultaneous measurement of acetyl-CoA and

Protocols

Retention occurs through polar interaction between the sorbent and analytes. Typical sample matrices that can be employed in normal-phase SPE include hydrocarbon or fatty oils diluted in a solvent like hexane, isooctane, chlorinated solvent, THF, diethyl ether, or ethyl acetate.

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