Titan C18 UHPLC Column, 1.9 micron

1.9 μm particle size, L × I.D. 10 cm × 2.1 mm


Quality Level


suitable for USP L1





extent of labeling

13% carbon loading


18000 psi pressure (1241 bar)
60 °C max. temp.


HPLC: suitable

L × I.D.

10 cm × 2.1 mm


monodisperse silica particle platform

matrix active group

C18 (octadecyl) phase

particle size

1.9 μm

pore size

0.76 cm3/g pore volume
80 Å pore size

surface area

410 m2/g

pH range

2 - 8

separation technique

reversed phase

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Legal Information

Titan is a trademark of Sigma-Aldrich Co. LLC

WGK Germany


  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. When are additional phases expected for Titan 1.9μm columns?

    Additional Titan 1.9μm phases are being developed and will encompass all aspects of UHPLC requirements.

  6. Are guard columns available for  Titan 1.9 μm C18 columns with 2.1 mm ID?

    Guard columns for Titan 1.9 μm C18 UHPLC columns with 2.1 mm ID are product 577127-U.  This product is a pack of three guard cartridges with dimensions 2.1 X 5 mm.   These cartridges require the use of the guard column holder, product 577133-U.

  7. Can I use Titan 1.9 μm columns on HPLC systems?

    Titan 1.9 μm columns are designed to be used only on UPLC or UHPLC systems.

  8. Which UHPLC Instruments can be used with Titan?

    Titan 1.9μm columns can be used on any UPLC or UHPLC System.

  9. What is the best practice for long-term storage of Titan C18 1.9 μm columns?

    Long-term storage of silica-based, reversed-phase columns is best in 100% acetonitrile. Columns may be safely stored for short periods (up to 3 or 4 days) in most common mobile phases. However, when using buffers, it is best to protect both the column and the HPLC equipment and remove any salts by flushing the column with the same mobile phase without the buffer (e.g., when using 60:40 ACN:buffer, flush the column with 60:40 ACN:H2O) to eliminate any danger of corrosion from the salts while providing rapid reequilibration of the column with the original mobile phase. Before storing the column, the end-fittings should be tightly sealed with the end-plugs that are provided with the column to prevent the packing from drying.

  10. What solvents are compatible with Titan C18 1.9 μm columns?

    Water and all common organic solvents are compatible with Titan C18 1.9 μm columns.

Fabrice Gritti et al.
Journal of chromatography. A, 1392, 10-19 (2015-03-24)
The kinetic performances of 3.0 × 100 mm columns packed with 1.9 μm Titan-C18 particles with average mesopore sizes of 80 Å and 120 Å were investigated quantitatively for the analysis of biomolecules. Large mesopores are expected to speed up...
Fabrice Gritti et al.
Journal of chromatography. A, 1355, 164-178 (2014-06-28)
In a previous report, it was reported that columns packed with fully porous 1.9μm Titan-C18 particles provided a minimum reduced plate height as small as 1.7 for the most retained compound (n-octanophenone) under RPLC conditions. These particles are characterized by...
Fabrice Gritti et al.
Journal of chromatography. A, 1355, 179-192 (2014-07-09)
The mass transfer mechanism in four prototype columns (2.1 and 3.0×50mm, 2.1 and 3.0×100mm) packed with 1.9μm fully porous Titan-C18 particles was investigated by using two previously reported home-made protocols. The first one was used to measure the eddy dispersion...
Fabrice Gritti et al.
Journal of chromatography. A, 1384, 76-87 (2015-02-11)
Previous data have shown that could deliver a minimum reduced plate height as small as 1.7. Additionally, the reduction of the mesopore size after C18 derivatization and the subsequent restriction for sample diffusivity across the Titan-C18 particles were found responsible...
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