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BP1100

Hydroxychloroquine sulfate

British Pharmacopoeia (BP) Reference Standard

Synonym(s):

7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate

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About This Item

Empirical Formula (Hill Notation):
C18H26ClN3O · H2SO4
CAS Number:
Molecular Weight:
433.95
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

agency

BP

API family

hydroxychloroquine

form

solid

shelf life

limited shelf life, expiry date on the label

packaging

pkg of 100 mg

manufacturer/tradename

BP

color

off-white

mp

238-241 °C

solubility

water: soluble

application(s)

pharmaceutical
pharmaceutical small molecule

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12

InChI

1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)

InChI key

JCBIVZZPXRZKTI-UHFFFAOYSA-N

Gene Information

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General description

Hydroxychloroquine Sulfate (Hydroxychloroquine Sulphate) is a salt of hydroxychloroquine (HCQ, Plaquenil), a 4-aminoquinoline based antiviral drug.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Hydroxychloroquine sulfate BP Reference standard, intended for use in laboratory tests only as specifically prescribed in the British Pharmacopoeia.

Also used in monographs such as:
  • Hydroxychloroquine Tablets
  • Biochem/physiol Actions

    Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

    Packaging

    Unit quantity: 100 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity please visit British Pharmacopoeia

    Other Notes

    Sales restrictions may apply.

    pictograms

    Exclamation mark

    signalword

    Warning

    Hazard Classifications

    Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

    Storage Class

    11 - Combustible Solids

    wgk_germany

    WGK 3

    flash_point_f

    Not applicable

    flash_point_c

    Not applicable


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    Famotidine
    British Pharmacopeia
    British Pharmacopoeia, 44(12), 1000-1004 (2020)
    Seminars in Arthritis and Rheumatism, 43(2), 264-272 (2013)
    A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spectrometry
    Fuzery AK, et al.
    Clinica Chimica Acta; International Journal of Clinical Chemistry, 421 (2013)
    Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood
    Charlier B,et al.
    Biomedical Chromatography, 32(8), e4258-e4258 (2018)
    Pharmacokinetics and bioequivalence study of hydroxychloroquine sulfate tablets in Chinese healthy volunteers by LC--MS/MS
    Fan HW, et al.
    Rheumatology and therapy, 2(2) (2015)

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