phyproof® Reference Substance

1,8-Dihydroxy 3-hydroxymethylanthraquinone, Rhabarberone, 1,8-Dihydroxy-3-(hydroxymethyl)anthraquinone, 3-Hydroxymethylchrysazine
Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
Pricing and availability is not currently available.

biological source



primary reference standard

product line

phyproof® Reference Substance


≥95.0% (HPLC)

mfr. no.


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Food and Beverages



storage temp.

room temp

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General description

Aloe-emodin, an anthraquinone derivative, is an active constituent of several medicinal plants. It shows gastrointestinal effects by exerting laxative activity.
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG


Aloe-emodin may be used as an analytical reference standard for the determination of the analyte in plant and animal samples by high-performance liquid chromatography technique.

Biochem/physiol Actions

Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG


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Hazard Statements

Precautionary Statements

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Simultaneous determination and pharmacokinetic studies of aloe emodin and chrysophanol in rats after oral administration of Da-Cheng-Qi decoction by high-performance liquid chromatography
Tang WF, et al.
Biomedical Chromatography, 21(7), 701-707 (2007)
Analysis of the anthraquinones aloe-emodin and aloin by gas chromatography/mass spectrometry
ElSohly MA, et al.
International Immunopharmacology, 4(14), 1739-1744 (2004)
Simultaneous determination of five anthraquinones in medicinal plants and pharmaceutical preparations by HPLC with fluorescence detection
He D, et al.
Journal of Pharmaceutical and Biomedical Analysis, 49(4), 1123-1127 (2009)
One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection
Gao XY, et al.
Journal of Chromatography A, 1216(11), 2118-2123 (2009)

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