USP

Desmethoxycurcumin

Name: Desmethoxycurcumin
Brand: USP
Price: 361.6 USD
Availability: InStock

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₈O₅

CAS Number:

22608-11-3

Molecular Weight:

338.35

MDL number:

MFCD03427310

UNSPSC Code:

41116107

NACRES:

NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

curcumin

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O(C)c1c(ccc(c1)\C=C\C(=O)CC(=O)\C=C\c2ccc(cc2)O)O

InChI

1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+

InChI key

HJTVQHVGMGKONQ-LUZURFALSA-N

Related Categories

Analytical Chemistry

Analytical Reference Materials for Pharma QC

Pharmacopeia & Metrological Institute Standards

Reference Materials

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1 of 4

This Item	1075305	1151855	1379434
USP 1173100 Desmethoxycurcumin	USP 1075305 Bisdesmethoxycurcumin	USP 1151855 Curcumin	USP 1379434 Meloxicam Related Compound C
manufacturer/tradename USP	manufacturer/tradename USP	manufacturer/tradename USP	manufacturer/tradename USP
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
API family curcumin	API family curcumin	API family curcumin	API family meloxicam

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Desmethoxycurcumin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Curcuminoids Tablets
Curcuminoids
Powdered Turmeric Extract
Powdered Turmeric
Turmeric

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Product No.

Description

Pricing

1075305

Bisdesmethoxycurcumin, United States Pharmacopeia (USP) Reference Standard

1151855

Curcumin, United States Pharmacopeia (USP) Reference Standard

1151866

Curcuminoids, United States Pharmacopeia (USP) Reference Standard

PHR2209

Curcumin, Pharmaceutical Secondary Standard; Certified Reference Material

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A novel approach to active compounds identification based on support vector regression model and mean impact value.

Jian-Lan Jiang et al.

Chemical biology & drug design, 81(5), 650-657 (2013-01-29)

Traditionally, active compounds were discovered from natural product extracts by bioassay-guided fractionation, which was with high cost and low efficiency. A well-trained support vector regression model based on mean impact value was used to identify lead active compounds on inhibiting

Demethoxycurcumin, a major active curcuminoid from Curcuma longa, suppresses balloon injury induced vascular smooth muscle cell migration and neointima formation: an in vitro and in vivo study.

Ming-Jyh Sheu et al.

Molecular nutrition & food research, 57(9), 1586-1597 (2013-03-23)

Curcumin has been shown to affect platelet-derived growth factor (PDGF)- and tumor necrosis factor (TNF)-α-elicited vascular smooth muscle cell (VSMC) migration and inhibit neointima formation following vascular injury. However, whether two other curcuminoids isolated from Curcuma longa, demethoxycurcumin (DMC) and

Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1.

Mei-Chun Kou et al.

Molecular nutrition & food research, 57(9), 1598-1610 (2013-02-07)

Curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) have been demonstrated as having antioxidant, anticarcinogenic, and hypocholesterolemic activities. We report the diverse antiatherogenic effects and mechanisms of curcuminoids. We found that CUR was the most potent antioxidant against copper-mediated LDL oxidation

Simultaneous determination of three Curcuminoids in Curcuma wenyujin Y.H.chen et C.Ling. by liquid chromatography-tandem mass spectrometry combined with pressurized liquid extraction.

Yan Shen et al.

Journal of pharmaceutical and biomedical analysis, 81-82, 146-150 (2013-05-08)

A sensitive and efficient method based on pressurized liquid extraction (PLE) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for simultaneous identification and quantification of three Curcuminoids in Curcuma wenyujin Y.H.chen et C.Ling., a well known traditional Chinese medicinal

Curcuminoid metabolism and its contribution to the pharmacological effects.

Kun Wang et al.

Current drug metabolism, 14(7), 791-806 (2013-08-14)

Curcuminoids are safe natural yellow pigments used as food coloring agents and traditional drugs with a variety of biological functions such as antitumor, anti-inflammatory and antioxidant activities. Poor oral bioavailability and the low plasma concentration of curcuminoids limited their clinical

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