1173508

USP

Desoximetasone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):
9-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione
Empirical Formula (Hill Notation):
C22H29FO4
CAS Number:
Molecular Weight:
376.46
MDL number:
NACRES:
NA.24
Pricing and availability is not currently available.

biological source

synthetic

Agency/Method

USP

vapor pressure

<0.0000001 kPa ( 25 °C)

form

powder

CofA

certificate is enclosed in each package

packaging

pkg of 200 mg

mfr. no.

USP

storage condition

protect from light

color

white

solubility

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

Featured Industry

Pharmaceutical (small molecule)

SMILES string

HC@@12CC@@H(C)C@H(C(=O)CO)C@@1(C)CC@H(O)C@@3(F)C@@2(H)CCC4=CC(=O)C=CC@34C

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

InChI key

VWVSBHGCDBMOOT-IIEHVVJPSA-N

Gene Information

human ... NR3C1(2908)

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General description

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

Application

Desoximetasone is used as an analytical standard for the determination of the analyte in pharmaceutical dosage forms by various analytical techniques.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Desoximetasone USP Monograph
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 44(2), 1272-1272 (2020)
Topical corticosteroids: mechanisms of action.
Kragballe, K
Acta Dermato-Venereologica. Supplementum, 151(3), 7-7 (1989)
Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Gorle A, et al.
Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
S Vladimirov et al.
Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product...
Protocols
A simple, precise and sensitive Reverse-Phase High Pressure Liquid Chromatography gradient method was adapted for traceability, homogeneity and total chromatographic analysis of Dexamethasone. The given experimental conditions follow the USP43-NF38 monograph method for Dexamethasone Assay and Organic Impurity Profiling. Dexamethasone, Betamethasone, Dexamethasone acetate and Desoximetasone were baseline resolved within 20 minutes using a Titan C18 UHPLC column (2.1 x 100 mm, 1.9 µm).
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