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1226003

USP

Doxycycline hyclate

United States Pharmacopeia (USP) Reference Standard

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Synonym(s):
Doxycycline hydrochloride hemiethanolate hemihydrate
Empirical Formula (Hill Notation):
C22H24N2O8 · HCl · 0.5H2O · 0.5C2H6O
CAS Number:
Molecular Weight:
512.94
Beilstein:
5702728
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

doxycycline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].[H]O[H].CCO.C[C@@H]1C2[C@H](O)C3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14.C[C@@H]5C6[C@H](O)C7[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]7(O)C(O)=C6C(=O)c8c(O)cccc58

InChI

1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10?,14?,15-,17-,22-;;;;/m00..../s1

InChI key

HALQELOKLVRWRI-ZVACAFRPSA-N

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1 of 4

This Item
BP78033429PHR1145
Doxycycline hyclate United States Pharmacopeia (USP) Reference Standard

USP

1226003

Doxycycline hyclate

Doxycycline hyclate British Pharmacopoeia (BP) Reference Standard

BP780

Doxycycline hyclate

Doxycycline hyclate VETRANAL®, analytical standard

Supelco

33429

Doxycycline hyclate

Doxycycline hyclate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1145

Doxycycline hyclate

manufacturer/tradename

USP

manufacturer/tradename

BP

manufacturer/tradename

-

manufacturer/tradename

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

clinical testing

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

doxycycline

API family

doxycycline

API family

-

API family

doxycycline

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-10 to -25°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Doxycycline hyclate USP reference standard suitable for use in specified USP compendial quality tests and assays.

Also used to prepare standard, system suitability stock, and sensitivity solution for the assay, impurity analysis, and performance test by using liquid chromatography in conjunction with UV detector according to the given below monographs of United States Pharmacopeia (USP): 
  • Doxycycline Hyclate
  • Doxycycline Hyclate Delayed-Release Tablet  
  • Doxycycline Tablets  
  • Doxycycline Capsules  
  • Doxycycline Hyclate Tablets

Biochem/physiol Actions

Mode of Action: Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi.

Activity Spectrum: Effective against a broad spectrum inhibitor of matrix metalloproteinases in vivo.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Signal Word

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Doxycycline Hyclate Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(2), 1537-1537 (2022)
Doxycycline Hyclate Delayed-Release Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 43(6), 1539-1539 (2022)
Doxycycline Tablets
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 1527-1527 (2022)
Doxycycline Hyclate
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(3) (2022)
Doxycycline Capsules
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(2), 1519-1519 (2022)

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