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Ifosfamide

Name: Ifosfamide
Brand: USP
Price: 455 USD

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Ifex, N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine-2-oxide

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Pack Size	SKU	Availability	Price
500 mg		Check Cart for Availability	$455.00

About This Item

Empirical Formula (Hill Notation):

C₇H₁₅Cl₂N₂O₂P

CAS Number:

3778-73-2

Molecular Weight:

261.09

NACRES:

NA.24

PubChem Substance ID:

329750149

UNSPSC Code:

41116107

MDL number:

MFCD00057374

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Properties

grade

pharmaceutical primary standard

API family

ifosfamide

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClCCNP1(=O)OCCCN1CCCl

InChI

1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)

InChI key

HOMGKSMUEGBAAB-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Ifosfamide is a nitrogen mustard compound that is a structural isomer of cyclophosphamide. Ifosfamide is a prodrug that must be transformed by cytochrome P450 to the biologically active component. It is used as an antineoplastic agent in cancer chemotherapy, but ifosfamide is more likely to cause renal toxicity than cyclophosphamide.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	I0060000	BP759	PHR3187
USP 1336205 Ifosfamide	I0060000 Ifosfamide	BP759 Ifosfamide	Supelco PHR3187 Ifosfamide
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename -
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical
format neat	format neat	format neat	format -
API family ifosfamide	API family ifosfamide	API family ifosfamide	API family ifosfamide
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H319,H340,H350,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Meta-analysis to assess the efficacy and toxicity of docetaxel-based doublet compared with docetaxel alone for patients with advanced NSCLC who failed first-line treatment.

Ying Jin et al.

Clinical therapeutics, 36(12), 1980-1990 (2014-09-27)

The benefit of docetaxel-based therapy in the second-line treatment of advanced non-small cell lung cancer (NSCLC) is still unclear. The goal of this meta-analysis was to assess the efficacy and toxicity of docetaxel-based doublet compared with docetaxel alone for patients

Cancer chemotherapy and cardiac arrhythmias: a review.

Juan Tamargo et al.

Drug safety, 38(2), 129-152 (2015-01-13)

Cardiovascular toxicity is a potential complication of cancer chemotherapy (CC) that increases the morbidity and mortality of cancer patients. Cardiac arrhythmias have been reported as an adverse effect of many chemotherapeutic drugs, including novel targeted therapies. The relationship between chemotherapy

Comparative study of the effects of antituberculosis drugs and antiretroviral drugs on cytochrome P450 3A4 and P-glycoprotein.

Yasuhiro Horita et al.

Antimicrobial agents and chemotherapy, 58(6), 3168-3176 (2014-03-26)

Predicting drug-drug interactions (DDIs) related to cytochrome P450 (CYP), such as CYP3A4 and one of the major drug transporters, P-glycoprotein (P-gp), is crucial in the development of future chemotherapeutic regimens to treat tuberculosis (TB) and TB/AIDS coinfection cases. We evaluated

Global Trade Item Number

SKU	GTIN
T3889-25G	04061833624777
1336205-500MG	04061833831502

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