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MilliporeSigma

1411005

USP

Methimazole

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1-Methyl-2-imidazolethiol, 2-Mercapto-1-methylimidazole

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200 MG

$455.00

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About This Item

Empirical Formula (Hill Notation):
C4H6N2S
CAS Number:
60-56-0
Molecular Weight:
114.17
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329750399
MDL number:
MFCD00179321
Beilstein/REAXYS Number:
108646

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InChI key

PMRYVIKBURPHAH-UHFFFAOYSA-N

InChI

1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7)

SMILES string

CN1C=CNC1=S

grade

pharmaceutical primary standard

API family

methimazole

manufacturer/tradename

USP

mp

144-147 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... TPO(7173)

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1 of 4

This Item
46429Y0000336M8506
Methimazole United States Pharmacopeia (USP) Reference Standard

USP

1411005

Methimazole

Methimazole VETRANAL®, analytical standard

Supelco

46429

Methimazole

Thiamazole European Pharmacopoeia (EP) Reference Standard

Y0000336

Thiamazole

Methimazole analytical standard

Supelco

M8506

Methimazole

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

EDQM

manufacturer/tradename

-

grade

pharmaceutical primary standard

grade

analytical standard

grade

pharmaceutical primary standard

grade

analytical standard

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
clinical
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

cleaning products
cosmetics
food and beverages
forensics and toxicology
personal care
pharmaceutical (small molecule)
veterinary

format

neat

format

neat

format

neat

format

neat

API family

methimazole

API family

-

API family

thiamazole

API family

-

mp

144-147 °C (lit.)

mp

144-147 °C (lit.)

mp

144-147 °C (lit.)

mp

144-147 °C (lit.)

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Methimazole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Methimazole Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardExclamation mark
GHS08,GHS07

flash_point_f

Not applicable

flash_point_c

Not applicable

target_organs

Endocrine system

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 1A - Skin Sens. 1 - STOT RE 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

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Ashish A Vyas et al.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 16(4), 673-676 (2010-05-05)
To report a case of a patient with Graves disease presenting with agranulocytosis induced by methimazole, with subsequent thyroid storm and successful therapeutic use of plasmapheresis. The clinical features and laboratory findings in a patient with agranulocytosis and thyroid storm
Fernando Bolaños et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 54(4), 307-310 (2002-11-06)
Long-term thionamide treatment is considered one of the main resources for Graves' hyperthyroidism. Although a 54.2% remission rate in patients so treated in Mexico was previously reported, most articles have shown a wide variation over time. In the present article
T Vogt et al.
The British journal of dermatology, 133(6), 994-996 (1995-12-01)
We report a child with scalp aplasia cutis congenita, whose mother was treated with methimazole during pregnancy. The relationship between antithyroid drug administration during pregnancy and the occurrence of scalp defects is discussed, and the pertinent literature is reviewed.
Roberto Gastaldi et al.
The Journal of pediatrics, 164(5), 1189-1194 (2014-02-13)
To evaluate clinical and biochemical features of 115 children (98 female, mean age 11.3 ± 3.5 years) with Graves disease to identify possible determinants of remission. We defined as positive outcome the improvement of clinical features and restoration of euthyroidism
P Barbero et al.
American journal of medical genetics. Part A, 129A(1), 83-86 (2004-07-22)
We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to
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