1514008

Phenacetin Melting Point Standard

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): p-Acetophenetidide, Acetophenetidin, 1-Acetyl-p-phenetidin, Phenacetin, 4′-Ethoxyacetanilide, N-(4-Ethoxyphenyl)acetamide
• Linear Formula: CH₃CONHC₆H₄OC₂H₅
• CAS Number: 62-44-2
• Molecular Weight: 179.22
• Beilstein: 1869238
• EC Number: 200-533-0
• MDL number: MFCD00009094
• PubChem Substance ID: 329750741
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• manufacturer/tradename: USP
• mp: 133-136 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: CCOc1ccc(NC(C)=O)cc1
• InChI: 1S/C10H13NO2/c1-3-13-10-6-4-9(5-7-10)11-8(2)12/h4-7H,3H2,1-2H3,(H,11,12)
• InChI key: CPJSUEIXXCENMM-UHFFFAOYSA-N

Description

General description

Phenacetin Melting Point Standard (Phenacetin) is a lipid-soluble drug with moderate solubility with aqueous solvents. Its oral absorption is based on formulation factors like particle size. Its major metabolic route is O-dealkylation to paracetamol and its minor pathways are deacetylation and hydroxylation to form pphenetidine, 2-hydroxyphenetidine, 2- and 3-hydroxyphenacetin and N-hydroxyphenacetin.

Biochem/physiol Actions

Substrate of CYP1A2 and CYP2D6.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.

Sales restrictions may apply.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Danger
• Hazard Statements: H302 - H350
• Precautionary Statements: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable