Salicylic acid

United States Pharmacopeia (USP) Reference Standard

2-Hydroxybenzoic acid
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
MDL number:
PubChem Substance ID:


pharmaceutical primary standard

vapor density

4.8 (vs air)

vapor pressure

1 mmHg ( 114 °C)






211 °C (lit.)


158-161 °C (lit.)


alcohol: freely soluble
benzene: slightly soluble
boiling water: soluble
chloroform: sparingly soluble
ether: freely soluble
toluene: slightly soluble
water: slightly soluble


1.44 g/cm3 at 20 °C

Featured Industry

Pharmaceutical (small molecule)



SMILES string




InChI key


Looking for similar products? Visit Product Comparison Guide

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

USP issued SDS can be found here.
Sales restrictions may apply.

Signal Word


Hazard Statements


NONH for all modes of transport

WGK Germany


Flash Point(F)

314.6 °F - closed cup

Flash Point(C)

157 °C - closed cup

Certificate of Analysis

Certificate of Origin

A Corina Vlot et al.
Annual review of phytopathology, 47, 177-206 (2009-04-30)
For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans. However, its extensive signaling role in plants, particularly in defense against pathogens, has only become evident during the past 20...
Ganesan Karthikeyan et al.
British journal of haematology, 146(2), 142-149 (2009-05-15)
Guidelines differ on whether acetyl salicylic acid (ASA, aspirin) should be used for prophylaxis in patients at high-risk of venous thromboembolism (VTE), principally because of differences in perceptions of its efficacy. ASA is an attractive therapeutic option because it is...
Tomonori Kawano et al.
Plant cell reports, 32(7), 1125-1138 (2013-05-22)
It is well recognized that salicylic acid (SA) acts as a natural signaling molecule involved in both local and systemic plant defense responses upon attacks by pathogens. Recently, cellular SA receptors and a number of SA-related phloem-mobile signals were identified....
Andrea Clavijo McCormick et al.
Plant, cell & environment, 37(8), 1909-1923 (2014-01-30)
After herbivory, plants release volatile organic compounds from damaged foliage as well as from nearby undamaged leaves that attract herbivore enemies. Little is known about what controls the volatile emission differences between damaged and undamaged tissues and how these affect...
Caroline Gutjahr et al.
Molecular plant-microbe interactions : MPMI, 22(7), 763-772 (2009-06-16)
Work on the interaction of aerial plant parts with pathogens has identified the signaling molecules jasmonic acid (JA) and salicylic acid (SA) as important players in induced defense of the plant against invading organisms. Much less is known about the...
Separation of Acetylsalicylic acid, analytical standard; Salicylic acid, BioXtra, ≥99.0%
Read More
Separation of Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance); Acetylsalicylic acid, purum, ≥99.0% (HPLC)
Read More
Separation of 4-Hydroxybenzoic acid; Acetylsalicylic acid; Benzoic acid; Salicylic acid; Ethyl 4-hydroxybenzoate
Read More

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.