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1653004

USP

Theophylline

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

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About This Item

Empirical Formula (Hill Notation):
C7H8N4O2
CAS Number:
58-55-9
Molecular Weight:
180.16
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329751262
MDL number:
MFCD00079619
Beilstein/REAXYS Number:
13463

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InChI

1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)

SMILES string

CN1C(=O)N(C)c2[nH]cnc2C1=O

InChI key

ZFXYFBGIUFBOJW-UHFFFAOYSA-N

grade

pharmaceutical primary standard

API family

theophylline

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

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Show Differences

1 of 4

This Item
T0800000BP3271653117
Theophylline United States Pharmacopeia (USP) Reference Standard

USP

1653004

Theophylline

Theophylline European Pharmacopoeia (EP) Reference Standard

T0800000

Theophylline

Theophylline British Pharmacopoeia (BP) Reference Standard

BP327

Theophylline

Theophylline melting point standard United States Pharmacopeia (USP) Reference Standard

USP

1653117

Theophylline melting point standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

manufacturer/tradename

USP

manufacturer/tradename

EDQM

manufacturer/tradename

BP

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical
pharmaceutical small molecule

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

theophylline

API family

theophylline

API family

theophylline

API family

theophylline, theophylline

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE3A(5139), PDE3B(5140), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Theophylline USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Aminophylline
  • Aminophylline Delayed-Release Tablets
  • Aminophylline Injection
  • Aminophylline Oral Solution
  • Aminophylline Rectal Solution
  • Aminophylline Tablets
  • Dimenhydrinate

Biochem/physiol Actions

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

comparable product

Product No.
Description
Pricing

related product

Product No.
Description
Pricing

T0800000

Theophylline, European Pharmacopoeia (EP) Reference Standard

1077708

8-Bromotheophylline, United States Pharmacopeia (USP) Reference Standard

1653048

Theophylline Related Compound D, United States Pharmacopeia (USP) Reference Standard

1653037

Theophylline Related Compound C, United States Pharmacopeia (USP) Reference Standard

1653026

Theophylline Related Compound B, United States Pharmacopeia (USP) Reference Standard

1653060

Theophylline Related Compound F, United States Pharmacopeia (USP) Reference Standard

BP327

Theophylline, British Pharmacopoeia (BP) Reference Standard

PHR2588

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2541

Theophylline Related Compound F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2551

Theophylline Related Compound D, Pharmaceutical Secondary Standard; Certified Reference Material

1121038

8-Chlorotheophylline, United States Pharmacopeia (USP) Reference Standard

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

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Amy T Ma et al.
Applied and environmental microbiology, 80(21), 6704-6713 (2014-08-26)
Cyanobacteria are photosynthetic bacteria that are currently being developed as biological production platforms. They derive energy from light and carbon from atmospheric carbon dioxide, and some species can fix atmospheric nitrogen. One advantage of developing cyanobacteria for renewable production of
Victoria Boswell-Smith et al.
The Journal of allergy and clinical immunology, 117(6), 1237-1243 (2006-06-06)
Theophylline has been relegated to a second- or even third-line therapy in the treatment of asthma and chronic obstructive pulmonary disease (COPD), behind glucocorticosteroids and beta2-agonists, although recent findings have suggested that theophylline possesses anti-inflammatory and immunomodulatory effects in addition
Diego Caccavo et al.
Molecular pharmaceutics, 12(2), 474-483 (2014-12-17)
In this work the behavior of hydrogel-based matrices, the most widespread systems for oral controlled release of pharmaceuticals, has been mathematically described. In addition, the calculations of the model have been validated against a rich set of experimental data obtained
Laura López-Cruz et al.
Behavioural brain research, 270, 213-222 (2014-05-27)
Caffeine and theophylline are methylxanthines that are broadly consumed, sometimes at high doses, and act as minor psychostimulants. Both are nonselective adenosine antagonists for A1 and A2A receptors, which are colocalized with dopamine D1 and D2 receptors in striatal areas.
David J Henderson-Smart et al.
The Cochrane database of systematic reviews, (1)(1), CD000273-CD000273 (2010-01-22)
Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia, which may be severe enough to require resuscitation including use of positive pressure ventilation.
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