Controlling the stereochemical outcome for various synthetic routes using chiral auxiliaries enables the synthesis of many enantiomerically pure compounds in a time-efficient manner. By temporarily attaching these structures to an organic compound, the auxiliary can influence the stereoselectivity of future reactions. Once the stereoselective protection is no longer needed, the chiral auxiliary can be removed and recycled for future uses. Asymmetric synthesis plays a crucial role in the chemical production of certain therapeutic and natural product compounds in enantiomeric form. We offer a market-leading range of innovative ephedrine derivatives, oxazolidinone derivatives, and sulfur-based chiral auxiliaries to aptly suit your applications.
Ephedrine, as well as ephedrine isomers and derivatives, play an important role in the preparation of optically active molecules, such as phosphine-phosphonite ligands, and allow for the synthesis of new molecules with stable configurations or unique confirmations. Our ligands have a stable non-carbon stererogenic center that allow them to assume roles as catalytic agents, chiral auxiliaries, or inductors in asymmetric organic synthesis.
Oxazolidinone derivatives have a well-established structure-activity relationship and are used in diastereoselective reactions for various asymmetric transformations. Our derivatives are frequently used in aldol, alkylation, or Diels-Alder reactions, and afterwards the steric hindrances are removed.
Our convenient sulfur-based chiral auxiliaries are effective as stereogenic groups and can be superior to other well-known chiral auxiliaries, depending on your application. Our auxiliaries are valuable for the synthesis of natural products and compounds with pharmacological activity for acetate aldol reactions, resolution of racemic mixtures, Michael additions, and intramolecular thio-Michael/aldol cyclization cascade reactions.
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