Halogenation Reagents

AlkylFluor structure – a halogenation reagent

Halogenation is fundamental tool in the organic chemist's toolbox for replacing a hydrogen atom with a halogen atom (fluorine, chlorine, bromide, or iodine). The use of halogenation reagents in various coupling protocols (e.g., Suzuki, Stille, Sonogashira) and nucleophilic substitution is prevalent and has been reported in the scientific community.

While several synthetic methods for the introduction of a halogen exist, there is still a need for efficient and practical methods for introducing other halogen-containing structural elements, in particular at a late-stage in synthesis (esp. with high yields and under mild conditions). Our readily available halogenation reagents may be used in many stages of your synthesis, and many are practical for use in late-stage development.

Our portfolio includes halogenation reagents for brominations, chlorinations, fluorinations, haloborations, and iodinations. With products such as AlkylFluor, XtalFluor®, PhenoFluor™, and PyFluor there are bench-stable reagent options for deoxyfluorination. We are dedicated to supporting all your explorations with our halogenated substrates.


Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon


Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.