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MilliporeSigma

Caustic Alkalis & Bases

Colorless or white pellets of a caustic base sodium hydroxide/potassium hydroxide

Life sciences encompass a wide range of activities—from complex chemical syntheses and analytical chemistry to routine laboratory work and large-scale production. Each application is governed by distinct regulatory requirements, making it essential to choose the right chemical products for your specific needs.

To simplify your search, we offer caustic alkalis and bases through three specialized portfolio brands, each tailored to a unique application area:

  • Sigma-Aldrich® – Designed for general lab use and production environments.
  • Supelco® – Ideal for analytical chemistry and precise laboratory testing.
  • SAFC® – products for biopharmaceutical and pharmaceutical development and manufacturing

Each brand provides a broad selection of alkalis and bases available in various volumes, packaging formats, and with all necessary documentation to meet compliance standards. Whether you're working in research, development, or production, you can easily find the right product to match your application and regulatory requirements.

Explore our portfolio to find the best solution for your life sciences workflow.


Products

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organic bases (182)

inorganic bases (132)

salts (47)

bases (37)

buffers (10)

building blocks (4)

liquid (156)

powder (77)

solid (31)

pellets (28)

powder or crystals (14)

solution (10)
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Ammonium hydroxide solution
221228

Ammonium hydroxide solution

ACS reagent, 28.0-30.0% NH3 basis

Potassium hydroxide
221473

Potassium hydroxide

ACS reagent, ≥85%, pellets

Sodium hydroxide
221465

Sodium hydroxide

ACS reagent, ≥97.0%, pellets

Sodium hydroxide
S5881

Sodium hydroxide

reagent grade, ≥98%, pellets (anhydrous)

Sodium bicarbonate
S6014

Sodium bicarbonate

ACS reagent, ≥99.7%

Sodium hydroxide
1.06498

Sodium hydroxide

pellets for analysis EMSURE®

Sodium hydroxide solution
415413

Sodium hydroxide solution

50% in H2O

<I>n</I>-Butyllithium solution
230707

n-Butyllithium solution

2.5 M in hexanes

Sodium carbonate
223530

Sodium carbonate

powder, ≥99.5%, ACS reagent

Sodium carbonate
222321

Sodium carbonate

ACS reagent, anhydrous, ≥99.5%, powder or granules

Potassium hydroxide
484016

Potassium hydroxide

reagent grade, 90%, flakes

Potassium carbonate
209619

Potassium carbonate

ACS reagent, ≥99.0%

Ammonium hydroxide solution
338818

Ammonium hydroxide solution

28% NH3 in H2O, ≥99.99% trace metals basis

Calcium carbonate
239216

Calcium carbonate

ACS reagent, ≥99.0%, powder

Ammonia solution 25%
1.05432

Ammonia solution

25%, for analysis EMSURE® ISO,Reag. Ph Eur

Potassium bicarbonate
237205

Potassium bicarbonate

ACS reagent, 99.7%, powder, crystals or granules

Sodium bicarbonate
S8875

Sodium bicarbonate

ReagentPlus®, ≥99.5%, powder

Sodium hypochlorite solution
425044

Sodium hypochlorite solution

reagent grade, available chlorine 10-15 %

Triethylamine
471283

Triethylamine

≥99.5%, liquid

Sodium hydroxide solution
72068

Sodium hydroxide solution

BioUltra, Molecular Biology, 10 M in H2O


 

Organic and Inorganic Bases for Chemical Synthesis and Laboratory Use

Organic and inorganic bases are available in multiple grades, tailored for everything from general laboratory use to sensitive chemical syntheses including the synthesis of GLP-1 agonists.

Caustic Alkalis and Bases for Sample Preparation and Analysis

Explore our range of EMSURE® and EMPLURA® caustic alkalis and bases available in various concentrations, quality grades, and packaging sizes. This includes sodium and potassium hydroxide pellets, solutions, and ammonia solutions designed to meet your analytical needs. Manufactured in a dedicated facility with top-tier raw materials and advanced technology, our NaOH and KOH pellets ensure uniform pellet sizes and minimal impurities. Enjoy high purity and consistent batch-to-batch quality for reliable, reproducible results.

EMPLURA® caustic alkalis and bases

For preparative work and cleaning, choose EMPLURA® caustic alkalis and bases, which offer essential specifications at a competitive price.

EMSURE® Caustic Alkalis and Bases for Pharmacopoeia Analysis 

EMSURE® caustic alkalis and bases are premium-grade products meet and even exceed global quality guidelines, including ACS and Reag. Ph Eur standards, ensuring broad acceptance in pharmaceutical quality control, simplifying audits, and reducing validation efforts and costs. Produced with high purity and batch-to-batch consistency, our caustic alkalis (NaOH and KOH pellets) deliver reliable, reproducible analytical results. They are available in various packaging sizes to accommodate diverse application needs.

High Purity Bases for Chromatography and Spectrometry

Lichropur high purity bases for HPLC and LC-MS analysis:

LiChropur® high purity bases are used in HPLC and LC-MS analysis to minimize background noise and signal suppression. These bases are application-tested by our quality control to meet our customers’ expectations.

Suprapur® and UltraPur® high-purity bases for ICP-OES, ICP-MS, AAS analysis

Suprapur® and Ultrapur® high-purity bases are used for inorganic trace and ultra-trace analysis. Each one of our analytical reagents is manufactured to clear the guaranteed specifications. The large variety of modern analytical methods (ICP-OES, ICP-MS, AAS, etc.) allow tailored control and analysis procedures for each product.

Volumetric solutions for Titration

Our Titripur® volumetric solutions and our Titrisol® concentrates offer a range of alkaline solution in different concentrations for quantifying compounds with the titration method. They are produced and analyzed under high-quality standards. The Titripur® solutions are analyzed by our DIN EN ISO/IEC 17025 accredited quality control lab. An innovation are our digital products with an RFID tag on the bottles to transfer data seamlessly.

Biopharmaceutical and pharmaceutical formulation and production products

Achieving consistent quality and regulatory compliance in biopharmaceutical manufacturing requires reliable raw materials and robust documentation. Our SAFC® portfolio provides high-purity process chemicals, solvents, and reagents manufactured under strict cGMP guidelines to support every stage from development and scale-up to commercial production. Through our Emprove® Program, each product is backed by comprehensive documentation that simplifies qualification, risk assessment, and regulatory submissions while ensuring full supply-chain transparency. With our technical expertise and customizable manufacturing options, we help you streamline process development and maintain confidence in your formulation and production workflows. Explore our Emprove® Chemicals portfolio and our complete range of bioprocessing and formulation raw materials to support your pharmaceutical and biopharmaceutical production needs.


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