3D Bioprinting
3D bioprinting is a novel technology that enables the generation of precisely controlled 3D tissue constructs with tissue-like complexity. 3D bioprinting is an additive manufacturing process which utilizes 3D printing techniques to build up materials and generate 3D tissue constructs in a layer-by-layer fashion.
Bioink, the material used in 3D bioprinting, contains living cells and biomaterials that mimic the extracellular matrix (ECM) environment to support cell adhesion, proliferation, and differentiation after printing. This emerging innovation has the potential to solve many critical unmet needs in medical research, with applications in cosmetics testing, drug discovery, in vitro models, and functional organ replacement.
We offer a comprehensive portfolio of biocompatible fit-for-purpose polymers, water-soluble photoinitiators, and additives specifically for 3D bioprinting and tissue engineering applications. Many of these specialty materials contain moieties that enable easy and fast crosslinking by exposure to UV or visible light, changes in pH, thermal methods like sample warming, or even by exposure to culture media.
Products
Hyaluronic acid adipic dihydrazide (HA-ADH)
TissueFab® bioink
(Gel)ma -UV/365 nm
Dextran aldehyde
40% degree of functionalization
Carboxymethyl cellulose glycidyl methacrylate
Degree of methacrylation ~10%
TissueFab® Discrete GelMA
90-110 bloom, 50% degree of substitution
TissueFab® bioink Conductive
Vis/405 nm
TissueFab® bioink
(Gel)ma -VIS/405nm, low endotoxin
TissueFab® GelAlg − LAP Bioink
low endotoxin, 0.2 μm filtered, suitable for 3D bioprinting applications
TissueFab® bioink Bone
Vis/405 nm
TissueFab® - low endotoxin GelMA-UV bioink
0.2 μm filtered, suitable for 3D bioprinting applications
TissueFab® bioink
Sacrificial
TissueFab® bioink
(GelHA)ma -Vis/405 nm
TissueFab® bioink
Alg(Gel)ma -Vis/525 nm
TissueFab® collagen bioink kit
neutral, Viscofan Fibercoll-Flex® N
TissueFab® bioink
Alg(Gel)ma -UV/365 nm
TissueFab® bioink
(GelAlgHA)ma -UV/365 nm
TissueFab® bioink Bone
support gel
TissueFab® bioink kit
(Gel)ma Fibrin (Vis/405), low endotoxin
TissueFab® bioink Conductive
Vis/405 nm, low endotoxin
Ovine collagen
lyophilized, low endotoxin
Product Features
- Our wide range of functionalized synthetic polymers with reactive end groups facilitate fabrication of functional hydrogels, even for those with limited chemistry knowledge.
- Our natural polymers, such as hyaluronic acid, chitosan, gelatin, alginate, and their derivatives, contain cross-linkable functional groups to recapitulate both mechanical and biochemical properties of the native extracellular matrix, and have the necessary surface chemistry for cell attachment, proliferation, and differentiation.
- Our thermally processable biodegradable polymers, such as polycaprolactones, polylactides and PLGAs, can be used for fabricating rigid structures. These materials have high strength and rigidity and provide structural support for tissue constructs designed to replicate bone.
- We are continuously adding to our ready-to-use bioinks for extrusion type 3D bioprinting. Our bioinks are based on a variety of biomaterials, including natural polymers, decellularized extracelluar matrix, synthetic polymers and synthetic peptides.
TissueFab® BIOINKS
Our TissueFab® bioinks offer a complete suite of ready-to-use bioink formulations with step-by-step protocols are optimized for high printing fidelity, cell viability, and batch-to-batch reproducibility.
Related Resources
- Article: 3D Bioprinting: Bioink Selection Guide
Bioinks enable 3D bioprinting of tissue constructs for drug screening and transplantation; select suitable bioinks for specific tissue engineering.
- Article: Bioprinting for Tissue Engineering and Regenerative Medicine
In the past two decades, tissue engineering and regenerative medicine have become important interdisciplinary fields that span biology, chemistry, engineering, and medicine.
- Article: Photo-Crosslinkable Gelatin Hydrogel: Versatile Materials for (High Resolution) Additive Manufacturing
Discussion of synthetic modifications to gelatin, improving the three-dimensional (3D) print resolution, and resulting material properties.
- Article: Three-Dimensional Bioprinting for Tissue and Disease Modeling
Professor Shrike Zhang (Harvard Medical School, USA) discusses advances in 3D-bioprinted tissue models for in vitro drug testing, reviews bioink selections, and provides application examples of 3D bioprinting in tissue model biofabrication.
- User Guide: 3D Bioprinting Handbook
This handbook is intended for all levels of researchers, both experts and non-experts in tissue engineering and in-vitro models for drug discovery.
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