Step-by-step Instructions for Nanoformulation Development
Drug delivery formulations are essential for the delivery, efficacy and stability of many active pharmaceutical ingredients (APIs) and have become exceedingly important with recent advancements in therapeutics, including mRNA vaccines and other nucleic acids.
Our NanoFabTx™ formulation kits are designed for facile and reproducible synthesis of nano- to micro-sized drug-loaded particles. Detailed protocols with step-by-step instructions are provided for nanoformulation development, eliminating the need for lengthy trial-and-error optimization. NanoFabTx™ formulation kits and lipid mixes can be used with traditional nanoprecipitation or extrusion methods or can be combined with the NanoFabTx™ microfluidic device kits for rapid synthesis of well-defined drug delivery particles.
Our NanoFabTx™ Drug Formulation Kits are designed to prepare specifically-sized polymeric micro- and nanoparticles for small molecule drug delivery. Each kit contains rationally selected polymers developed and tested by our formulation scientists. Our NanoFabTx™ Formulation Screening Kits make polymer selection and optimization easy by providing multiple polymers to choose from including PEGylated and non-PEGylated biodegradable polymers PLA, PLGA, and PCL.
Liposomes are widely used for a range of therapeutics including small molecules, nucleic acids (mRNA, siRNA, DNA), proteins, and peptides. Our NanoFabTx™ lipid formulation mixes are curated lipid blends for liposome preparation. We offer a variety of lipid mixes to best suit your nanoformulation needs including PEGylated, cationic, and functionalized liposomes.
Microfluidic devices provide a platform for rapid and reproducible microparticle, nanoparticle, lipid nanoparticle, and liposome fabrication. Unlike traditional methods, microfluidics-based nanoparticle synthesis results in controlled particle size and small size distribution and can easily be scaled up to produce larger batch sizes needed for preclinical trials.
Our NanoFabTx™ microfluidic device kits include a pre-assembled microfluidic glass chip, tubing and accessories and can be directly connected to a syringe pump or pressurized pump system, such as Dolomite Microfluidics Mitos P-Pump. The NanoFabTx™ microfluidic device kits are designed to work together with our NanoFabTx™ drug formulation kits and lipid mixes.
Article: Material Matters 14.3 – Advanced Tools for Drug Delivery Research
Article: Polymeric Drug Delivery Techniques
Article: NanoFabTx™ – A ready-to-use Microfluidic Platform for mRNA Vaccine Formulation
Article: NanoFabTx™ Nanoparticle and mRNA Liposome Formulation Using the NanoAssemblr®
Brochure: The Future of Drug Delivery: Lyophilized Liposome Flyer
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