MilliporeSigma

Bioprocessing Mobius® Single-Use Bioreactors

Whether you are looking to introduce modular single-use bioreactors into your current process or whether you are investigating how you can increase your manufacturing flexibility to accommodate all types of upstream processing (batch, fed-batch, and perfusion processes), Mobius® products and solutions can help you meet your evolving cell culture needs.

The Mobius® Bioreactor family includes the bench scale (2 mL and 3 L), pilot, clinical and commercial manufacturing (50 – 2,000 L) bioreactors that enable cell culturing capabilities from early process development through commercial batch production.

Mobius® single-use bioreactors include products to help you work faster and more cost-effectively. Our experts will partner with you throughout the process to help you meet your goals. 


BENCHTOP SINGLE-USE BIOREACTORS

Mobius® Breez Microbioreactor

Mobius® Breez Microbioreactor

2 mL automated single-use perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell processes. The system is capable of accelerating a range of applications such as cell line development, media screening and optimization, and early process development. The Mobius® Breez Microbioreactor allows you to increase efficiency and reduce development timelines and costs over traditional technologies that require more material consumption.


Benefits

  • Enables perfusion processes to achieve high cell densities in 2 mL
  • Freedom from hands-on work with automated control and monitoring
  • Operational flexibility allows you to save on development time and costs​
Mobius® iFlex Bioreactor 200 L in perfusion mode

Mobius® 3 L Single-Use Bioreactor

Single-use stirred tank bioreactor for bench-scale cell culture in fed-batch or perfusion mode. It combines the predictability of a stirred tank design with the flexibility of single use, making it the ideal solution for bench scale cell culture process development.​

Benefits​

  • Maximize laboratory resources by saving days of downtime between experiments ​
  • Compatible with wide range of controllers, eliminating the need to purchase additional equipment to switch to a single-use solution
  • Comparable functionality to conventional glass bioreactors

PILOT, CLINICAL & COMMERCIAL SINGLE-USE BIOREACTORS

Mobius® iFlex Bioreactor 200 L in perfusion mode

Mobius® iFlex Bioreactors

Future-proof your process with modular flexibility today.

Start your transition into the biomanufacturing facility of the future with the Mobius® iFlex Bioreactors—a modular, next-generation, high-performing, perfusion-ready bioreactor, with unparalleled design that can support ultra-high cell densities.

The new Mobius® iFlex Bioreactors are a scalable portfolio of stirred tank bioreactors that leverages single-use bags with enhanced strength, made with our innovative Ultimus® film. Perfusion applications are supported with ease by integrating a perfusion tower, that uses the Cellicon® Filter Assemblies to retain cells in the bioreactor vessel while removing spent media.

Benefits

  • High performance with enhanced mixing and oxygen transfer
  • Flexibility to fulfill batch, fed-batch and
    perfusion processes
  • Scalability from 50 L to 2000 L

Products


Related Product Resources

  • /deepweb/assets/sigmaaldrich/product/documents/254/771/mobius-breez-microbioreactor-ds12130en-ms.pdf

    The Mobius® Breez Microbioreactor is a 2 mL automated single-use perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell processes. The system is capable of accelerating a range of applications such as cell line development, media screening and optimization, and early process development.

  • Article: Process Analytical Technology (PAT)

    Process Analytical Technology (PAT) is a regulatory framework initiated by the United States’ Food and Drug Administration (FDA) that encourages innovation in pharmaceutical development, manufacturing, and quality assurance. The goal of PAT is to build quality into biopharmaceutical production processes by monitoring and controlling the process in real time.


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Related Services

System Service Reliance Plans

Our system service reliance plans and maintenance services provide critical...

*System Service Reliance Plan not applicable to Mobius® 3 L Bioreactor

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