MilliporeSigma

Cell Therapy Manufacturing Systems

The ekko™ Acoustic Cell Processing System is a breakthrough technology that provides freedom from process limitations in cell therapy manufacturing. Its unique acoustic technology provides a gentle way of processing cells while maintaining cell quality. Its unmatched ease-of-use and flexibility support multiple cell applications, process steps, and scales.

The ekko™ System is flexible for a range of cell types and variations including without limitation to:

  • Wash
  • Concentration
  • Media Exchange
  • Low Volume Processing
  • Formulation


Products


Key Benefits

  • High cell recovery and viability with residual removal of >95%
  • Simple and ergonomic installation of ekko™ Single-Use Assemblies
  • ekko™ Software and ekko™ Architect, our flexible protocol development tool, is designed for easy navigation and use
  • Freedom from process limitations - for use in multiple unit operations across a variety of cell types
  • Low volume processing enabling collection of 5 mL cell concentrate
  • 21 CFR Part 11 compliance-ready and developed under GAMP5 guidelines

The ekko™ Acoustic Cell Processing System is flexible for a range of cell types and variations including without limitation to:

  • T cells
  • Pluripotent Stem Cells (iPSCs)
  • Mesenchymal Stem Cells (MSCs)
  • Hematopoietic Stem Cells (HSCs)

Concentrate display screen example for ekko Software

ekko™ Software and ekko™ Architect

Intuitive Navigation

Our touchscreen interface allows for fast navigation and quick response rates that support increased productivity.

Step-by-Step Instructions

Graphical step-by-step instructions reduce error and simplify training and technology transfer.

Multiple Modes of Operation

The ekko™ Software offers two (2) modes of operation:

  • The Development Mode allows for process development and protocol optimization.
  • The Manufacturing Mode locks procedures for execution in compliance with 21 CFR Part 11.

ekko System Single-Use Assembly

ekko™ Single use Assembly

Ready to Process in Minutes

Our single-use assembly installs in less than a minute. Simple tube welds connect incoming material, product, and waste bags.

Error Proof Set-up

We have designed our single-use assembly for error-proof installation. Latches ensure secure attachment before starting your run. In addition, to improve operational safety and ease of use, all weldable tubes are labeled for easy identification.

Ergonomic Design

We have ergonomically designed the single-use assembly to integrate all fluid path components into a cartridge format that circumvents the need for manual tube threading through pinch valves or incorrect orientation of lines. In addition, the ekko™ Software controls all functions to ensure reliable and repeatable operation.

Maximum Operational Flexibility

We provide two tubing options for each weldable tube line: Thermoplastic elastamor (TPE) and Polyvinyl chloride (PVC). These options maximize operational flexibility, allowing you to select the correct transfer assemblies for your needs.