MilliporeSigma

Downstream purification in bioprocessing includes one or more chromatographic separation steps to purify your molecule and remove impurities. Our broad chromatography portfolio includes resins, membranes, columns, and systems that work seamlessly together to simplify your workflow from process development to production scale.

Backed by unparalleled applications expertise and comprehensive support, we provide the confidence you need to tackle any chromatography challenge in your downstream process to increase productivity and improve efficiency. 

Stainless steel chromatography column on wheels, designed for bioprocessing applications, featuring a transparent central chamber with measurement markings and a top-mounted handwheel for precision adjustments.
Chromatography Columns for Bioprocessing

Chromatography columns are critical to the successful separation of your valuable molecules. We provide columns from lab scale to pilot and process scale. From screening to large-scale production, our columns provide robust and consistent performance with the processing flexibility you need. 

Chromatograph system for bioprocessing, featuring various tubes, dials, and components, predominantly silver with blue accents and a logo featuring the letter ‘M’ on the side panel.
Chromatography Systems

Single-use and multi-use chromatography systems are critical for the separation of your valuable molecules. We provide standard and custom systems from pilot to process-scale, offering robust and consistent performance with the processing flexibility you need.

A scientist in a lab coat working with equipment and chemicals in a laboratory setting. In the foreground, there are three chemical containers with labels, two are large and one is smaller, marked with hazard symbols for flammable and corrosive substances.
Affinity Chromatography Resins

Affinity chromatography is often used during the capture phase to isolate the target molecule and reduce process volume. Our range of affinity resins includes Protein A, anti-A and anti-B, and metal chelate resin, designed for high throughput and cost-effective purification.

A complex industrial machine with various tubes, dials, and components, predominantly silver with blue accents and a logo featuring the letter ‘M’ on the side panel.
Downstream Process & Formulation Chemicals

Downstream and formulation chemicals ensure the yield and safety of your drug product throughout the downstream process. Supporting high-risk applications, our chemicals are multi-compendial and manufactured according to GMP guidelines.

Two chromatography columns designed for membrane chromatography applications, with one column being tall and slender, featuring measurement markings, and the other being shorter and wider with a volume label near its base, both presented against a plain white backdrop.
Membrane Chromatography

Membrane chromatography is a highly productive downstream purification technology used for capture through polishing. Natrix® chromatography membrane is a single-use solution which improves process economics and facility utilization when compared to traditional membrane adsorbers.

Set of ion exchange chromatography resin containers of varying sizes, with the largest on the right displaying a blue diamond-shaped hazard symbol, and two smaller bottles in front with white labels and blue text, all against a white background.
Ion Exchange Chromatography Resins

Ion exchange (IEX) chromatography separates biomolecules based on difference in charge between the target molecule and chromatography resin. Widely used in bioprocessing, our anion and cation exchange chromatography resins efficiently purify mAbs, recombinant proteins, vaccines, plasma, and other therapeutic molecules.

Two white industrial resin containers with black lids, labeled for use in size exclusion chromatography, on a white background.
Size Exclusion Chromatography Resins

Size exclusion chromatography (SEC) is a purification method used for separating substances based on their molecular size. Widely used in commercial bioseparation processes, size exclusion chromatography is a versatile technique because buffer composition does not impact separation effectiveness.

Two bottles of chromatography resins, one small and one large, labeled for reverse phase/normal phase applications, with a white and blue label design featuring the ‘M’ logo.
Reverse Phase/Normal Phase Chromatography Resins

High-performance liquid chromatography (HPLC) is a crucial step in the separation and purification of complex biomolecules. Our broad portfolio of normal-phase and reverse-phase silica gel resins economically delivers the excellent separation and high purity you need.

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