Ion Exchange Chromatography Resins
Ion exchange (IEX) chromatography is a commonly used purification method that separates a target molecule from other impurities based on the net surface charge. Our portfolio of anion exchange (AEX) and cation exchange (CEX) resins, with our multi-modal chromatography resins, offers efficient purification solutions for mAbs, vaccines, plasmid DNA, plasma, and other modalities.
Products
Fractogel® EMD SO3 ⁻ (M) Resin
strong cation exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Fractogel® EMD TMAE (M)
strong anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Fractogel® EMD TMAE Hicap (M)
strong anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Eshmuno® CPX Resin
Natrix® Q Micro
Natrix® Q Micro (0.2 mL), pack of 10 devices
Fractogel® EMD COO- (M)
weak cation exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Eshmuno® CPS Resin
Eshmuno® CMX Resin
Eshmuno® CMX
Fractogel® EMD DMAE (M)
weak anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Eshmuno® CP-FT Resin
Fractogel® EMD SE Hicap (M)
strong cation exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Fractogel® EMD DEAE (M)
weak anion exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
Natrix® Q Pilot
Natrix® Q Pilot (15 mL), pack of 1 device
Fractogel® EMD TMAE Hicap (M)
MiniChrom Column Fractogel® TMAE Hicap (M), volume 5 mL, prepacked column
Fractogel® EMD TMAE (M)
MiniChrom Column Fractogel® TMAE (M), volume 5 mL, prepacked column
Fractogel® EMD SO3 ⁻ (M) Resin
MiniChrom Column Fractogel® SO3 (M), volume 5 mL, prepacked column
Natrix® Q Process 600
Natrix® Q Process 600 (460 mL), pack of 1 device
Natrix® CH Bench
Natrix® CH Bench (8.8mL), pack of 1 device
Eshmuno® HCX Resin
Eshmuno® HCX
Fractogel® EMD TMAE (M)
MiniChrom Column Fractogel® TMAE (M), volume 1 mL, prepacked column
These resins are ideal for efficient downstream purification and contain our proven tentacle ligand technology coupled with rigid base beads. They operate at fast flowrates and maintain high binding capacities, improving productivity by reducing time and manufacturing costs.
Eshmuno® CMX mixed-mode resin provides high selectivity for mAbs, fusion proteins, and ADC purification, as well as separation of low molecular weight impurities and HCPs.
Eshmuno® CP-FT resin efficiently removes mAb aggregates in flow-through mode, resulting in 10 times higher loading capacities as compared to traditional bind/elute CEX chromatography. This enables process intensification while reducing the overall cost for downstream mAb purification.
Eshmuno® CPS resin offers high dynamic binding capacity and separation efficiency of recombinant protein feed streams at elevated salt concentrations. This enables direct loading of high-conductivity feed streams (conductivity ≥10 mS/cm), reducing the need for dilution.
Eshmuno® CPX resin effectively separates mAb monomers from aggregates and other impurities including HCP. It delivers superior dynamic binding capacity and enables high-resolution purification of process intermediates with outstanding productivity.
Eshmuno® HCX resin provides fast, efficient, direct capture of proteins, delivering outstanding performance in typical ion exchange and flow-through applications at higher salt levels.
Eshmuno® S is a strong CEX resin for direct capture of recombinant proteins and fast, efficient mAb purification following protein A capture.
Eshmuno® Q is a strong anion resin, offering superior dynamic binding capacity and outstanding impurity removal in typical anion exchange flow-through applications.
Fractogel® EMD IEX chromatography resins
All Fractogel® EMD resins provide high selectivity coupled with consistent pressure stability, enabling very high throughput and excellent yields. The resin’s high binding capacity, even at high flow rates, saves valuable time and improves process economics. Fractogel® resins are offered in different bead sizes with multiple functional groups to meet a range of purification needs:
Fractogel® strong anion exchangers
- Fractogel® EMD TMAE (S) Resin
- Fractogel® EMD TMAE (M) Resin
- Fractogel® EMD TMAE Hicap (M) Resin
- Fractogel® EMD TMAE Medcap (M) Resin
Fractogel® weak anion exchangers
Fractogel® strong cation exchangers
Fractogel® weak cation exchangers
Support for qualification, risk assessment, and process optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Resources
- Guide: Biochromatography Portfolio
Bulk Resin, Membranes and Prepacked Columns
- Guide: Chromatography Purification Selection
Protein A Affinity Chromatography Options
- Data Sheet: Eshmuno® CMX Resin
A highly selective mixed mode chromatography resin for difficult to purify mAbs, ADCs and fusion proteins
- Data Sheet: Eshmuno® CP‑FT Resin
A cation exchange resin specifically developed for the flow-through removal of aggregates using frontal chromatography
- Data Sheet: Eshmuno® CPS
High capacity and salt tolerance for recombinant protein purification
- Data Sheet: Eshmuno® CPX
Efficient impurity removal and strong binding capacity at high flow rates
- Data Sheet: Eshmuno® HCX Media
New, high salt-tolerant multi-mode chromatography resin
- Data Sheet: Eshmuno® S Resin for Superior Downstream mAB Purification
For superior downstream mAB purification
- Data Sheet: Eshmuno® Q Resin for Efficient AEX Chromatography
Eshmuno® Q resin is a strong anion exchange (AEX) resin, coupling our renowned tentacle structure with a hydrophilic polyvinyl ether base matrix
- Data Sheet: Fractogel® Chromatography Resin
Fractogel® resins consist of synthetic methacrylate based polymeric beads providing excellent pressure stability resulting in high flow rates
- Data Sheet: Robocolumn® and Minichrom Chromatography Columns
Small-scale prepacked chromatography columns for rapid process development, method optimization, parameter screening and sample preparation
- Article: Viral Clearance in Antibody Purification Using Tentacle Ion Exchangers
Manufacturers strive toward cost-effective purification of target molecules and a high level of confidence that their biologics are safe and not compromised by the presence of endogenous retrovirus-like particles or adventitious viruses.
- Article: Bioprocessing Technology Trends of RNA-based Therapeutics and Vaccines
This article reviews the current dynamics in the RNA therapeutics/vaccines market as well as differences between small-interfering RNA (siRNA), RNA interference (RNAi), microRNA (miRNA), and messenger RNA (MRNA).
- Article: RNA-Based Therapeutics and Vaccines
New Technologies Are Emerging to Overcome Challenges Associated with Toxicity and Drug Delivery.
- Application Note: ADC Separation Using a Mixed Mode Cation Exchange Chromatography Step in a mAb Process
The aim of this technical note is to provide a description of the steps followed and considerations taken during the development of antibody drug conjugate separation using a mixed mode cation exchange chromatography step.
- Application Note: Intensified Polishing Using Single-pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
The bioprocessing industry is interested in Next Generation Processes with higher flexibility, lower costs, and higher product quality.
- Application Note: Eshmuno® CMX Application Note on Glycovariant Separation Including for COVID-19
The aim of this technical note is to provide a description of the capture and subsequent purification of glycoproteins.
- Tech Note: Development Strategy for a Cation Exchange (CEX) Chromatography Step in a Monoclonal Antibody (mAb) Process
The aim of this technical note is to provide a description of the steps followed and considerations taken during the development of a CEX chromatography step in a mAb process.
- Article: Purification of Extracellular Vesicles with Eshmuno® Q Resin and Natrix® Q Membrane
Separation and purification of subpopulations of extracellular vesicles (EVs) using Eshmuno® Q anion exchange resin and Natrix® Q membrane chromatography.
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