Viral safety is a key consideration in biomanufacturing, assuring drug safety for patients. Virus filtration or nanofiltration separates virus based on size and is an important component of viral safety assurance in both upstream and downstream processes. Our trusted Viresolve® solutions are designed to deliver high performance at every step.
Our Viresolve® Barrier filters are the last line of defense against upstream bioreactor contamination and contain polyethersulfone (PES) membrane optimized for cell culture media filtration.
In processes with limited options for viral clearance downstream, these filters may be the preferred option for additional protection against adventitious agent contamination –particularly against virus, mycoplasma, and bacteria.
These capsule filters are easy to implement, install, and integrity test. They can also be easily connected to single-use systems. All filters are scalable from bench through commercial manufacturing and are 100% integrity tested in manufacturing, ensuring quality and consistency.
The Viresolve® Pro Solution provides a comprehensive flexible template for viral clearance in downstream processing of both monoclonal antibodies (mAbs) and recombinant proteins. This proven virus filtration solution delivers the highest levels of virus retention and productivity across a broad range of operating conditions.
These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing. All Viresolve® Pro Devices are 100% integrity tested in manufacturing, ensuring quality and consistency.
Prefilters bind protein aggregates and other process impurities that limit the capacity of small-pore virus filters such as the Viresolve® Pro Device. Implementing prefilters improves the capacity and consistency of virus filtration operations. Our prefilter portfolio includes:
These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing.
Viresolve® Barrier filters and the Viresolve® Pro Solution are supported by the Emprove® Program which provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory certificates in a readily available format.
These filters complement our broad portfolio of products and services, supported by teams with decades of technical expertise providing complete solutions that can meet your upstream and downstream viral safety needs.
Performance Guide: Viresolve® Barrier Filters
Application Note: Cell Culture Media Performance using Viresolve® Barrier Filters
Application Note: Robust Removal of Minute Virus of Mice from Cell Culture Media
White Paper: A Holistic Approach to Mitigating Contamination Risks
Article: Advances in Upstream Technologies Reduce Viral-Contamination
Article: Upstream Virus Safety – Protect Your Bioreactor with Media Filtration
Poster: Upstream Virus Safety: Protect Your Bioreactor
Poster: Implementation of a Virus Barrier Media Filter into Fed-batch Bioprocesses
Webinar: A Holistic Approach to Upstream Viral Safety
Webinar: Defend Your Bioreactor: Barrier Filtration as a Key Part of an Upstream Virus Safety Strategy
Webinar: Bioreactor Protection with the Viresolve® Barrier Filter
Video: Viresolve® Pro Solution Overview
Application Note: Virus Retention Performance of Viresolve® Pro Devices under a Range of Processing Conditions
Application Note: Multi-tier Approach to Assuring Virus Retention and Integrity of Viresolve® Pro Devices
Application Note: Scalability of the Viresolve® Pro Solution Using the Micro 40 Scaling Tool
Product Guide: Viresolve® Pro Solution Prefilter Selection Guide
Article: Virus Filtration Process Development Optimization
Poster: Quality by Design (QbD) Approach to Virus Filtration Operations
Brochure: The Science of Managing Change for Filters
Brochure: Viral Safety Assurance: Prevent, Detect, Remove
Webinar: Viral Clearance with Viresolve® Pro Solution: Prefiltration Strategies for Optimizing Performance
Webinar: Parvovirus-retentive Filter Performance and Removal Mechanisms During Process Interruptions
Webinar: Evaluating Viral Clearance for Continuous Processes
Webinar: Quality by Design for Virus Filtration
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