Virus Filters

Viresolve® Barrier capsules and Viresolve® Pro Devices used to assure viral safety in cell culture media and downstream processing

Viral safety is a key consideration in biomanufacturing, assuring drug safety for patients. Virus filtration or nanofiltration separates virus based on size and is an important component of viral safety assurance in both upstream and downstream processes. Our trusted Viresolve® solutions are designed to deliver high performance at every step.

Viresolve® Barrier filters for cell culture media processing

Our Viresolve® Barrier filters are the last line of defense against upstream bioreactor contamination and contain polyethersulfone (PES) membrane optimized for cell culture media filtration.

In processes with limited options for viral clearance downstream, these filters may be the preferred option for additional protection against adventitious agent contamination –particularly against virus, mycoplasma, and bacteria.

  • ≥ 3.0 log removal of parvovirus
  • ≥ 4.0 log removal of bacteriophage Phix 174 (φX 174)
  • ≥ 6.0 log removal of mycoplasma
  • Sterilizing-grade protection from bacteria

These capsule filters are easy to implement, install, and integrity test. They can also be easily connected to single-use systems. All filters are scalable from bench through commercial manufacturing and are 100% integrity tested in manufacturing, ensuring quality and consistency.

Viresolve® Pro Solution for filtration in downstream processes

The Viresolve® Pro Solution provides a comprehensive flexible template for viral clearance in downstream processing of both monoclonal antibodies (mAbs) and recombinant proteins. This proven virus filtration solution delivers the highest levels of virus retention and productivity across a broad range of operating conditions.

  • High mass capacity for improved process economics
  • High flux for faster processing
  • Consistent batch-to-batch performance
  • Robust virus retention: ≥ 4 log removal of parvovirus

These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing. All Viresolve® Pro Devices are 100% integrity tested in manufacturing, ensuring quality and consistency.

Prefilters for consistent filtration performance

Prefilters bind protein aggregates and other process impurities that limit the capacity of small-pore virus filters such as the Viresolve® Pro Device. Implementing prefilters improves the capacity and consistency of virus filtration operations. Our prefilter portfolio includes:

  • Viresolve® Pro Shield: surface modified membrane filter with cation exchange adsorptive chemistry, offering caustic stability and low extractables
  • Viresolve® Pro Shield H: surface modified membrane filter with mixed-mode adsorptive chemistry, offering caustic stability and low extractables
  • Viresolve® Prefilter: adsorptive depth filter enabling mixed mode adsorptive and hydrophobic binding, offering autoclave compatibility

These disposable filters are easy to use and are offered in small-scale formats for process development and viral clearance studies, as well as larger formats for pilot and commercial manufacturing.

Quality standards and documentation

Viresolve® Barrier filters and the Viresolve® Pro Solution are supported by the Emprove® Program which provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory certificates in a readily available format.

These filters complement our broad portfolio of products and services, supported by teams with decades of technical expertise providing complete solutions that can meet your upstream and downstream viral safety needs.



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Highlights

Viresolve® Barrier capsules and Viresolve® Pro Devices used to assure viral safety in cell culture media and downstream processing
Flyer: Viresolve® Pro Solution: Robust Productive, Proven

Our virus filtration solution provides the highest levels of retention assurance and productivity.

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