Originally developed by Singulex®, Inc., Single Molecule Counting (SMC™) technology, utilizing the SMCxPRO™ and Erenna® instruments, enables researchers to measure femtogram levels of biomarkers and better understand the clinical relevance from healthy to disease. Providing maximum immunoassay performance while following a workflow similar to traditional ELISA technology, SMC™ technology combines a unique assay elution step and robust digital counting to achieve improved signal-to-noise ratios over traditional immunoassay technologies. The SMC™ technology thus provides enhanced quantification at both low and high levels of expression on one complete system. Learn more about our SMC™ technology, immunoassay kits, and how you can design your own custom assay to meet your critical research needs.
The SMCxPRO™ and Erenna® instruments capture the sum of all digital events counted above the background threshold. The digital event algorithm of the SMCxPRO™ instrument computes digital events across a spectrum of time series for a single standard. On the Erenna® instrument, at lower concentrations, photons are digitally counted as single molecules. At higher concentrations, molecules are counted in analog and a proprietary algorithm computes the total sum of all photons recorded. The digital counting of molecules thus improves the assay sensitivity and extending the assay dynamic range beyond what can be achieved with traditional methods.
A comprehensive set of criteria evaluating ultimate quantitative performance are used to qualify verified immunoassays, including:
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