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Bharathi Avula et al.
Journal of AOAC International, 92(2), 633-644 (2009-06-03)
A simple and specific analytical method for the quantitative determination of flavonoids from the aerial parts of the Artemisia afra plant samples was developed. By column high-performance liquid chromatography (HPLC) with UV absorption and mass spectrometry (MS) detection, separation was...
Acacetin, a natural flavone, selectively inhibits human atrial repolarization potassium currents and prevents atrial fibrillation in dogs
Li GR, et al.,
Circulation, 117(19), 2449-2457 (2008)
Mei-Hua Gao et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 31(5), 682-684 (2008-10-02)
To study the chemical constituents of the flowers of Chrysanthemum indicum. Chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography. The structures were identified by means of physico-chemical and spectral data. From the 80% ethanol...
Hui-Jun Wu et al.
Journal of molecular and cellular cardiology, 51(6), 966-973 (2011-09-13)
We have demonstrated that the natural flavone acacetin selectively inhibits ultra-rapid delayed rectifier potassium current (I(Kur)) in human atria. However, molecular determinants of this ion channel blocker are unknown. The present study was designed to investigate the molecular determinants underlying...
Guang-Chun Piao et al.
Natural product research, 26(16), 1483-1491 (2011-10-20)
Artemisia sacrorum Ledeb. was extracted by 95% ethanol and water, respectively. By partitioning the 95% ethanol extract successively with different solvents and separating the water extract by macroporous resin, nine separate parts were obtained. According to the results of in...
Wei-Jan Huang et al.
Journal of ethnopharmacology, 166, 18-22 (2015-03-15)
Previously, we found a patient with an intractable motor tic disorder that could be ameliorated by the ground leaf juice of Clerodendrum inerme (CI). Furthermore, the ethanol extract of CI leaves effectively ameliorated methamphetamine-induced hyperlocomotion (MIH) in mice, an animal...
Haijin Shen et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(2), 191-193 (2010-04-17)
To develop a RP-HPLC method for the determination of quercetin, luteolin, apigenin and acacetin in Flos Chrysanthemi indici. An Eclipse XDB-C18 column (4.6 mm x 250 mm, 5 microm) was used at 25 degrees C with the mobile phases of...
Chuan-shan Jin et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 35(5), 702-704 (2012-12-12)
To investigate the effect of different processing methods on the content of luteolin-7-O-beta-D-glucoside, acacetin-7-O-beta-D-glucoside, luteolin, and acacetin of Dendranthema morifolium. The optimal conditions were achieved on phenomenex, synergi Fusion-RP (5 microm, 4.6 mm x 250 mm)analytical column with a gradient...
Dasol Kim et al.
Communications biology, 4(1), 1-1 (2021-01-06)
Disorders of autophagy, a key regulator of cellular homeostasis, cause a number of human diseases. Due to the role of autophagy in metabolic dysregulation, there is a need to identify autophagy regulators as therapeutic targets. To address this need, we...
Panpan Guo et al.
Journal of separation science, 38(7), 1156-1163 (2015-01-27)
A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and four phenolic acids in the total flavonoids extract...
Qiaofeng Wu et al.
Fitoterapia, 81(5), 429-433 (2009-12-17)
An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based...
María Eva González-Trujano et al.
Planta medica, 78(8), 793-796 (2012-04-05)
Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of...
Yaou Fong et al.
Journal of food science, 75(1), H30-H38 (2010-05-25)
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, has antiperoxidative and antiinflammatory effects. The effect of acacetin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMPs and u-PA expressions in human lung cancer A549 cells was investigated. First, the result demonstrated acacetin could inhibit TPA-induced the abilities of...
Monika Warat et al.
International journal of molecular sciences, 15(7), 11510-11522 (2014-07-01)
Expression level of Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) receptors is one of the most important factors of TRAIL-mediated apoptosis in cancer cells. We here report for the first time data concerning TRAIL-R1 and TRAIL-R2 receptor expression on RAW264.7 macrophages....
Si-Yang Fan et al.
Journal of ethnopharmacology, 141(2), 647-652 (2011-05-31)
As a Chinese traditional herbal medicine, leaves of Platycladus orientalis (Linnaeus) Franco (LPO) are used to treat coughs, excessive mucus secretion, chronic bronchitis, bronchiectasis, and asthma, etc. The experiments were carried out to investigate their anti-inflammatory properties and mechanisms, which...
Hui-Jun Wu et al.
PloS one, 8(3), e57864-e57864 (2013-03-26)
The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (Ito) in human atrial myocytes. However, the molecular determinants of acacetin for blocking Ito are unknown. The present study was designed to investigate the properties and molecular...
Jidan Liu et al.
Carbohydrate research, 357, 41-46 (2012-06-27)
Apigenin-7-O-β-D-glycosides 1-8 and acacetin-7-O-β-D-glycosides 9-16 were semisynthesized from 4'-O-benzyl apigenin 17 and acacetin 18 by glycosidation and deprotection with the corresponding α-acetylglycosyl bromide, respectively. Compounds 17 and 18 were prepared by iodination followed by base-induced elimination, 4'-O-benzylation, or 4'-O-methylation and...
Vasilis P Androutsopoulos et al.
Toxicology, 264(3), 162-170 (2009-08-12)
Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by...
Jinyue Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(6), 718-721 (2010-06-16)
To investigate the chemical constituents of the flowers of Chrysanthemum indicum. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. Twelve compounds were isolated and identified as acacetin (1), tricin (2), 2',4'-dihydroxychalcone(3)...
Hana Moon et al.
PloS one, 10(5), e0127060-e0127060 (2015-05-16)
Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with...
Jianping Zhao et al.
Journal of ethnopharmacology, 120(3), 387-393 (2008-10-25)
Damiana (Turnera diffusa Willd. Ex Schult) has traditionally been used as an herbal aphrodisiac. The study was aimed to investigate the anti-aromatse activity and the estrogenic activity of the constituents isolated from Turnera diffusa. The methanolic extract and 24 compounds...
Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis
Hsu YL, et al.,
Biochemical Pharmacology, 67(5), 823-829 (2004)
Juha-Pekka Salminen et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(5-6), 437-444 (2008-11-13)
The metabolic modifications of birch (Betula pubescens Ehrh.) leaf phenolics in the digestive tract of its major defoliator, larvae of the autumnal moth Epirrita autumnata, were studied. The main phenolic acids of birch, i.e. chlorogenic and p-coumaroylquinic acids, were isomerised...
Jie Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(2), 238-242 (2012-06-29)
Further study on the chemical constituents of Artemisia sphaerocephala led to the isolation of fifteen compounds. These compounds were isolated and purified by repeated column chromatography on silica gel and Sephadex LH-20. Their structures were determined by physicochemical properties and...
Kun-Hung Shen et al.
Molecular and cellular biochemistry, 333(1-2), 279-291 (2009-08-21)
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, has anti-peroxidative and anti-inflammatory effects. The effect of acacetin on antimetastasis in human prostate cancer DU-145 cells was investigated. First, the result demonstrated acacetin could exhibit an inhibitory effect on the abilities of the adhesion...
Alessandra Berto et al.
Food & function, 6(9), 3081-3090 (2015-07-28)
Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For...
Xue Wang et al.
Scientific reports, 5, 16127-16127 (2015-11-05)
The human β-amyloid (Aβ) cleaving enzyme (BACE-1) is a target for Alzheimer's disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole Agastache rugosa plant had anti-BACE-1 and behavioral activities in Drosophila melanogaster AD models...
Juriyati Jalil et al.
Molecules (Basel, Switzerland), 17(9), 10893-10901 (2012-09-12)
The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8)-flavonylflavanonol together with two known flavonoids...
Antifungal and antioxidant activities of heartwood, bark, and leaf extracts of Robinia pseudoacacia
Hosseinihashemi SK, et al.
BioResources, 11(1), 1634-1646 (2016)
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