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Hana Moon et al.
PloS one, 10(5), e0127060-e0127060 (2015-05-16)
Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways. Previously, we identified methyl syringate as an hTRPA1 agonist with
Jianping Zhao et al.
Journal of ethnopharmacology, 120(3), 387-393 (2008-10-25)
Damiana (Turnera diffusa Willd. Ex Schult) has traditionally been used as an herbal aphrodisiac. The study was aimed to investigate the anti-aromatse activity and the estrogenic activity of the constituents isolated from Turnera diffusa. The methanolic extract and 24 compounds
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Antifungal and antioxidant activities of heartwood, bark, and leaf extracts of Robinia pseudoacacia
Hosseinihashemi SK, et al.
BioResources, 11(1), 1634-1646 (2016)
Acacetin inhibits the proliferation of Hep G2 by blocking cell cycle progression and inducing apoptosis
Hsu YL, et al.,
Biochemical Pharmacology, 67(5), 823-829 (2004)
Jie Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(2), 238-242 (2012-06-29)
Further study on the chemical constituents of Artemisia sphaerocephala led to the isolation of fifteen compounds. These compounds were isolated and purified by repeated column chromatography on silica gel and Sephadex LH-20. Their structures were determined by physicochemical properties and
Juriyati Jalil et al.
Molecules (Basel, Switzerland), 17(9), 10893-10901 (2012-09-12)
The methanol extract of the leaves of Garcinia nervosa var. pubescens King, which showed strong inhibitory effects on platelet-activating factor (PAF) receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8)-flavonylflavanonol together with two known flavonoids
Juha-Pekka Salminen et al.
Zeitschrift fur Naturforschung. C, Journal of biosciences, 59(5-6), 437-444 (2008-11-13)
The metabolic modifications of birch (Betula pubescens Ehrh.) leaf phenolics in the digestive tract of its major defoliator, larvae of the autumnal moth Epirrita autumnata, were studied. The main phenolic acids of birch, i.e. chlorogenic and p-coumaroylquinic acids, were isomerised
Xue-Jing Peng et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 34(10), 1534-1537 (2012-03-01)
To study the chemical constitutes of Buddleja davidii. The constitutes were isolated and purified by silica gel column chromatography, polyamide column chromatography and macroporous absorption resin and their structures were elucidated by spectroscopic analysis. Seven compounds including Apigenin (1), Apigenin-7-O-beta-D-glucoside
Alessandra Berto et al.
Food & function, 6(9), 3081-3090 (2015-07-28)
Among the large number of scientifically unstudied fruits from the Amazonia biome, Couepia bracteosa acts as an interesting source of bioactive compounds, such as phenolic compounds and carotenoids, which may be used for protecting human health against oxidative damage. For
Xue Wang et al.
Scientific reports, 5, 16127-16127 (2015-11-05)
The human β-amyloid (Aβ) cleaving enzyme (BACE-1) is a target for Alzheimer's disease (AD) treatments. This study was conducted to determine if acacetin extracted from the whole Agastache rugosa plant had anti-BACE-1 and behavioral activities in Drosophila melanogaster AD models
Ling-Zhi Liu et al.
Biochemical and biophysical research communications, 413(2), 299-305 (2011-09-07)
Acacetin (5,7-dihydroxy-4'-methoxyflavone) is a flavone compound, some of which have anti-cancerous effects. Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis and tumor growth. In this study, we found that acacetin decreased the steady level of VEGF mRNA
Soyeon Hong et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 84, 153517-153517 (2021-02-25)
Osteoporosis is a metabolic skeletal disease characterized by bone loss and an increased risk of fractures. This study aimed to investigate the therapeutic effect of Agastache rugosa on postmenopausal osteoporosis and elucidate its mechanisms in modulating the bone status. In
Shang-Tao Chien et al.
Molecular and cellular biochemistry, 350(1-2), 135-148 (2011-01-07)
Lung cancer is one of the most common malignancies in the world and its metastasis is the major cause of death in cancer patients. Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, has anti-peroxidative and anti-inflammatory effects. The effect of acacetin on invasion
Kiyotada Watanabe et al.
Oncology reports, 27(1), 204-209 (2011-10-14)
Flavonoids are naturally occurring antioxidants, with several flavonoids shown to have chemopreventive effects on cancer. We investigated the effects of the flavonoid acacetin on human T cell leukemia Jurkat cells. Acacetin inhibited the proliferation of Jurkat cells by inducing apoptosis
Vasilis P Androutsopoulos et al.
Bioorganic & medicinal chemistry, 19(9), 2842-2849 (2011-04-13)
CYP1A1 and CYP1B1 are two extrahepatic enzymes that have been implicated in carcinogenesis and cancer progression. Selective inhibition of CYP1A1 and CYP1B1 by dietary constituents, notably the class of flavonoids, is a widely accepted paradigm that supports the concept of
Daniela Ribeiro et al.
Inflammation, 38(2), 858-870 (2014-08-21)
Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the
Ning Zhao et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 34(4), 1359-1372 (2014-10-11)
Acacetin, a natural flavonoid compound, has been proven to exert anti-inflammatory and immunomodulatory effects. Kv1.3 channels, highly expressed in human T cells, are attractive therapeutic targets to treat inflammatory and immunological disorders. The present study was designed to characterize the
Hyo Geun Kim et al.
Biological & pharmaceutical bulletin, 35(8), 1287-1294 (2012-08-07)
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a constituent of flavone naturally present in plants, has anti-cancer and anti-inflammatory activities. Neuroinflammation is thought to be one of the major pathological mechanisms responsible for Parkinson's disease (PD), and has been a primary target in the development
Kun-Hung Shen et al.
Molecular and cellular biochemistry, 333(1-2), 279-291 (2009-08-21)
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, has anti-peroxidative and anti-inflammatory effects. The effect of acacetin on antimetastasis in human prostate cancer DU-145 cells was investigated. First, the result demonstrated acacetin could exhibit an inhibitory effect on the abilities of the adhesion
Panpan Guo et al.
Journal of separation science, 38(7), 1156-1163 (2015-01-27)
A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and four phenolic acids in the total flavonoids extract
Jidan Liu et al.
Carbohydrate research, 357, 41-46 (2012-06-27)
Apigenin-7-O-β-D-glycosides 1-8 and acacetin-7-O-β-D-glycosides 9-16 were semisynthesized from 4'-O-benzyl apigenin 17 and acacetin 18 by glycosidation and deprotection with the corresponding α-acetylglycosyl bromide, respectively. Compounds 17 and 18 were prepared by iodination followed by base-induced elimination, 4'-O-benzylation, or 4'-O-methylation and
Jinyue Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 35(6), 718-721 (2010-06-16)
To investigate the chemical constituents of the flowers of Chrysanthemum indicum. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data. Twelve compounds were isolated and identified as acacetin (1), tricin (2), 2',4'-dihydroxychalcone(3)
María Eva González-Trujano et al.
Planta medica, 78(8), 793-796 (2012-04-05)
Agastache mexicana is a plant in high demand that has long been used in Mexican folk medicine to treat anxiety, insomnia, and stomachache, among other afflictions. Ursolic acid and acacetin were isolated and identified as two possible active compounds of
Vasilis P Androutsopoulos et al.
Toxicology, 264(3), 162-170 (2009-08-12)
Among the different mechanisms proposed to explain the cancer-protecting effect of dietary flavonoids, substrate-like interactions with cytochrome P450 CYP1 enzymes have recently been explored. In the present study, the metabolism of the flavonoids chrysin, baicalein, scutellarein, sinensetin and genkwanin by
Hui-Jun Wu et al.
PloS one, 8(3), e57864-e57864 (2013-03-26)
The natural flavone acacetin has been demonstrated to inhibit transient outward potassium current (Ito) in human atrial myocytes. However, the molecular determinants of acacetin for blocking Ito are unknown. The present study was designed to investigate the properties and molecular
Qiaofeng Wu et al.
Fitoterapia, 81(5), 429-433 (2009-12-17)
An ethanolic extract and ethyl acetate fraction (EFMS) prepared from Mosla scabra showed potential inhibition against influenza viruses. The compounds isolated from EFMS were elucidated to be ursolic acid (1), 5-hydroxy-6,7-dimethoxyflavone (2), 5-hydroxy-7,8-dimethoxyflavone (3), apigenin (4) and acacetin (5) based
Monika Warat et al.
International journal of molecular sciences, 15(7), 11510-11522 (2014-07-01)
Expression level of Tumor Necrosis Factor-related apoptosis-inducing ligand (TRAIL) receptors is one of the most important factors of TRAIL-mediated apoptosis in cancer cells. We here report for the first time data concerning TRAIL-R1 and TRAIL-R2 receptor expression on RAW264.7 macrophages.
Si-Yang Fan et al.
Journal of ethnopharmacology, 141(2), 647-652 (2011-05-31)
As a Chinese traditional herbal medicine, leaves of Platycladus orientalis (Linnaeus) Franco (LPO) are used to treat coughs, excessive mucus secretion, chronic bronchitis, bronchiectasis, and asthma, etc. The experiments were carried out to investigate their anti-inflammatory properties and mechanisms, which
Dasol Kim et al.
Communications biology, 4(1), 1-1 (2021-01-06)
Disorders of autophagy, a key regulator of cellular homeostasis, cause a number of human diseases. Due to the role of autophagy in metabolic dysregulation, there is a need to identify autophagy regulators as therapeutic targets. To address this need, we
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