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Richard A Deitrich
Journal of studies on alcohol, 65(5), 557-572 (2004-11-13)
The possibility that acetaldehyde is responsible for some of the central nervous system effects of ethanol has been a popular hypothesis for many years. This review examines the evidence of a role for acetaldehyde in the actions of ethanol in
Lucía Martí-Prats et al.
Neuropharmacology, 72, 204-214 (2013-05-07)
Recent electrophysiological evidence suggests that ethanol simultaneously exerts opposite effects on the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) through two parallel mechanisms, one promoting and the other reducing the GABA release onto VTA DA neurons.
Peter Landolt et al.
Journal of economic entomology, 107(2), 654-660 (2014-04-30)
Orange mint moths, Pyrausta orphisalis (Walker) (Crambidae), were initially trapped in a study of noctuid moth attraction to floral volatiles. A subsequent series of trapping experiments in commercial mint fields determined that phenylacetaldehyde and 4-oxoisophorone were attractive to P. orphisalis
V S Shubina et al.
Bulletin of experimental biology and medicine, 154(1), 152-157 (2013-01-19)
We studied the effect of liposome preparation containing taxifolin oligomers and taxifolin conjugates with carbonyl compounds on skin regeneration after chemical burn. The preparations containing flavonoid conjugates intensified regeneration processes and reparation of hair follicles and sebaceous glands after chemical
Tetsuji Yokoyama et al.
Alcoholism, clinical and experimental research, 29(4), 622-630 (2005-04-19)
Elevated mean corpuscular volume (MCV) is a traditional biological marker for alcohol abuse and alcoholism, but the underlying mechanism is unclear. Three recent epidemiologic studies consistently showed that MCV was elevated by alcohol drinking more markedly among individuals with genetically
Masayoshi Takeuchi et al.
Journal of neuropathology and experimental neurology, 62(5), 486-496 (2003-05-29)
The Maillard reaction that leads to the formation of advanced glycation end products (AGEs) plays an important role in the pathogenesis of angiopathy in diabetic patients, in aging, and in neurodegenerative processes. We hypothesize that acetaldehyde (AA), one of the
Raghu Sivaramakrishnan et al.
The journal of physical chemistry. A, 119(28), 7724-7733 (2015-03-21)
The mechanism for the thermal decomposition of acetaldehyde has been revisited with an analysis of literature kinetics experiments using theoretical kinetics. The present modeling study was motivated by recent observations, with very sensitive diagnostics, of some unexpected products in high
Victor R Preedy et al.
Novartis Foundation symposium, 285, 158-177 (2007-06-27)
Alcoholic myopathy is characterized by biochemical and morphological lesions within muscle, ranging from impairment of muscle strength and loss of lean tissue to cellular disturbances and altered gene expression. The chronic form of the disease is five times more common
A W Jones et al.
Journal of analytical toxicology, 13(4), 199-203 (1989-07-01)
In the course of analyzing blood samples from drunk drivers, several low molecular weight volatiles were occasionally identified in addition to ethanol on the gas chromatograms. Among 21, 153 blood specimens analyzed during 1986, 77 contained ethanol as well as
Acetaldehyde links alcohol consumption to cancer.
Adrian Burton
The Lancet. Oncology, 6(9), 643-643 (2005-09-16)
Olga V Tyulina et al.
Biochimica et biophysica acta, 1762(5), 558-563 (2006-04-25)
Analysis of the oxidative modification of plasma and erythrocyte ghost proteins of chronic alcoholic subjects and healthy non-alcoholics has been performed. It was found that increased levels of protein carbonyls in both plasma and erythrocyte ghosts from alcoholic subjects occurred
D K Dastur et al.
The British journal of nutrition, 36(2), 143-159 (1976-09-01)
1. The B-vitamin status of fifty-nine patients, mainly from the lower socio-economic classes in Bombay, with a history of chronic malnutrition, and of alcoholism of 1-5-20 years' duration, was studied before and during treatment, and in relation to their clinical
Fusae T Nishimura et al.
Autonomic neuroscience : basic & clinical, 102(1-2), 60-70 (2002-12-21)
The present study was designed to investigate the effects of aldehyde dehydrogenase-2 (ALDH2) genotype on cardiovascular and endocrine responses to alcohol ingestion in young, healthy Japanese subjects. For this purpose, we monitored changes in the electrocardiogram (ECG), blood pressure (BP)
Xiaofa Qin et al.
Toxicology letters, 232(2), 356-362 (2014-12-03)
Acute and/or chronic alcohol ingestion has been shown to exacerbate the morbidity and mortality rate associated with acute mechanical and/or thermal trauma. While alcohol ingestion can affect many organs and systems, clinical and preclinical studies indicate that alcohol ingestion can
Alfonso Pérez-Garrido et al.
Bioorganic & medicinal chemistry, 17(2), 896-904 (2008-12-06)
This paper reports a QSAR study for predicting the complexation of a large and heterogeneous variety of substances (233 organic compounds) with beta-cyclodextrins (beta-CDs). Several different theoretical molecular descriptors, calculated solely from the molecular structure of the compounds under investigation
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces
Soichiro Yamabe et al.
The FEBS journal, 280(7), 1617-1629 (2013-02-05)
Mammalian cells attempt to maintain their homeostasis under endoplasmic reticulum (ER) stress. If the stress cannot be alleviated, cells are led to apoptosis through induction of C/EBP homologous protein (CHOP). ER stress is provoked in osteoarthritis chondrocytes, and intracellular accumulation
Ikuo Ueta et al.
Analytical and bioanalytical chemistry, 407(3), 899-905 (2014-09-10)
A novel miniaturized sample extraction capillary was developed to provide a simple and sensitive method for analyzing gaseous formaldehyde (FA) using conventional high-performance liquid chromatography (HPLC). The extraction capillary was prepared by packing silica gel particles in a stainless steel
Mikko Salaspuro
Journal of digestive diseases, 12(2), 51-59 (2011-03-16)
Aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH) gene polymorphisms associating with enhanced acetaldehyde exposure and markedly increased cancer risk in alcohol drinkers provide undisputable evidence for acetaldehyde being a local carcinogen not only in esophageal but also in gastric cancer.
W G Brydon et al.
European journal of gastroenterology & hepatology, 8(2), 117-123 (1996-02-01)
To assess the reliability of serum 7 alpha-hydroxy-4-cholesten-3-one (7 alpha-3ox-C) in the differential diagnosis of bile acid induced diarrhoea by comparison with 75selenohomocholyltaurine whole body retention (SeHCAT WBR). One hundred and sixty-four patients with chronic diarrhoea were investigated prospectively in
M P Mascia et al.
Alcoholism, clinical and experimental research, 25(11), 1570-1575 (2001-11-15)
Some of the effects of ethanol in the central nervous system are due to changes in function of ligand-gated ion channels. Production of detectable amounts of acetaldehyde, a primary metabolite of ethanol, has been demonstrated in brain homogenates. The aim
David Leitsch et al.
Experimental parasitology, 134(3), 374-380 (2013-04-13)
Our previous observation that NADP-dependent secondary alcohol dehydrogenase (ADH-1) is down-regulated in metronidazole-resistant Trichomonas vaginalis isolates prompted us to further characterise the enzyme. In addition to its canonical enzyme activity as a secondary alcohol dehydrogenase, a pronounced, so far unknown
H Matsuse et al.
The Journal of allergy and clinical immunology, 108(5), 715-719 (2001-11-03)
We have previously reported that alcohol-induced asthma in Japanese patients is caused by increased blood acetaldehyde concentration resulting from abnormalities of acetaldehyde dehydrogenase 2 (ALDH2) enzyme activity on the basis of ALDH2 genotype differences. The purpose of the present study
Marlena K Sheridan et al.
Food chemistry, 177, 17-22 (2015-02-11)
Wine tannins undergo modifications during fermentation and storage that can decrease their perceived astringency and increase color stability. Acetaldehyde acts as a bridging compound to form modified tannins and polymeric pigments that are less likely to form tannin-protein complexes than
T W Boyden et al.
European journal of pharmacology, 70(4), 571-576 (1981-04-09)
Utilizing a method for perfusion of the in vivo isolated canine testis we have examined basal and human chorionic gonadotropin (hGC)-stimulated testosterone production of testes acutely exposed to ethanol and acetaldehyde. Ethanol infused at concentrations of 0.2 g/dl to 0.6
Sarah E Frey et al.
Journal of the Air & Waste Management Association (1995), 64(11), 1251-1259 (2014-12-17)
A survey of key indoor air quality (IAQ) parameters and resident health was carried out in 72 apartments within a single low-income senior housing building in Phoenix, Arizona. Air sampling was carried out simultaneously with a questionnaire on personal habits
Douglas L Huseby et al.
Journal of bacteriology, 195(12), 2864-2879 (2013-04-16)
Microcompartments are loose protein cages that encapsulate enzymes for particular bacterial metabolic pathways. These structures are thought to retain and perhaps concentrate pools of small, uncharged intermediates that would otherwise diffuse from the cell. In Salmonella enterica, a microcompartment encloses
Takuya Kitamura et al.
The Biochemical journal, 465(1), 79-87 (2014-10-07)
Aldehyde dehydrogenases (ALDHs) catalyse the conversion of toxic aldehydes into non-toxic carboxylic acids. Of the 21 ALDHs in mice, it is the ALDH3 family members (ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2 and ALDH3B3) that are responsible for the removal of lipid-derived aldehydes.
Hyeong-Geug Kim et al.
World journal of gastroenterology, 20(42), 15703-15714 (2014-11-18)
To evaluate protective effects of Chunggan extract (CGX), a traditional herbal formula, under 4 wk of alcohol consumption-induced liver injury. Male Sprague-Dawley Rats were orally administered 30% ethanol daily for 4 wk with or without CGX. The pharmaceutical properties were
Tetsushi Azuma et al.
Journal of plant physiology, 170(13), 1158-1164 (2013-04-18)
Gravitropic curvature of pulvini of wheat and oat stem segments gradually declined with decreasing atmospheric O₂ concentration and was almost completely blocked under anoxia, whereas that of rice stem segments was enhanced under hypoxia and anoxia. Anoxia substantially increased the
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