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01-3460

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Gerald H Jordan et al.
BJU international, 114(1), 16-24 (2014-01-23)
Peyronie's disease (PD) is often physically and psychologically devastating for patients, and the goal of treatment is to improve symptoms and sexual function without adding treatment-related morbidity. The potential for treatment-related morbidity after more invasive interventions, e.g. surgery, creates a...
Harish Rajak et al.
European journal of medicinal chemistry, 53, 390-397 (2012-05-01)
Histone deacetylase inhibitors have been actively explored as a new generation of chemotherapeutics for cancers, generally known as epigenetic therapeutics. Two novel series of N-(2-amino-phenyl)-4-{[(2/3/4-substituted-phenylcarbamoyl)-methyl]-amino}-butyramide and N-(2-amino-phenyl)-4-{[(2/3/4-substituted-phenylcarbamoyl)-methyl]-amino}benzamide were designed and synthesized as novel histone deacetylase inhibitors. The anticancer potential of...
Ling Liu et al.
European journal of pharmacology, 691(1-3), 61-68 (2012-07-25)
O(2)-(2,4-dinitro-5-{[2-(12-en-28-β-D- galactopyranosyl-oleanolate-3-yl) -oxy-2-oxoethyl]amino}phenyl)1-(N-hydroxyethylmethylamino)diazen-1-ium-1,2- diolate (NG), a novel PABA/NO-based derivative of oleanolic acid (OA), has been found to show potent antitumor activity both in vivo and in vitro. In the present study, NG could significantly reduce tumor volume and weight in...
Djeneb Camara et al.
The Journal of biological chemistry, 287(26), 22367-22376 (2012-05-12)
Glutamine amidotransferase/aminodeoxychorismate synthase (GAT-ADCS) is a bifunctional enzyme involved in the synthesis of p-aminobenzoate, a central component part of folate cofactors. GAT-ADCS is found in eukaryotic organisms autonomous for folate biosynthesis, such as plants or parasites of the phylum Apicomplexa....
Tatsuki Fukami et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 78, 47-53 (2015-07-15)
Human arylacetamide deacetylase (AADAC) is an esterase responsible for the hydrolysis of some drugs, including flutamide, indiplon, phenacetin, and rifamycins. AADAC is highly expressed in the human liver, where carboxylesterase (CES) enzymes, namely, CES1 and CES2, are also expressed. It...
Jo Waaler et al.
Cancer research, 72(11), 2822-2832 (2012-03-24)
Increased nuclear accumulation of β-catenin, a mediator of canonical Wnt signaling, is found in numerous tumors and is frequently associated with tumor progression and metastasis. Inhibition of Wnt/β-catenin signaling therefore is an attractive strategy for anticancer drugs. In this study...
Gabriel B Akanni et al.
Journal of the science of food and agriculture, 95(5), 1094-1102 (2014-11-06)
The cladodes of Opuntia ficus-indica (prickly pear cactus) have a low protein content; for use as a balanced feed, supplementation with other protein sources is therefore desirable. We investigated protein enrichment by cultivation of the yeasts Candida utilis and Kluyveromyces...
Fernando H Cincotto et al.
Talanta, 147, 328-334 (2015-11-26)
This work describes the preparation of an electrochemical immunosensor for ethinylestradiol (EE2) based on grafting of diazonium salt of 4-aminobenzoic acid onto a glassy carbon electrode modified with silver nanoparticles/SiO2/graphene oxide hybrid followed by covalent binding of anti-ethinylestradiol (anti-EE2) to...
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be...
S Ito et al.
Clinical chemistry, 28(2), 323-326 (1982-02-01)
We describe a liquid-chromatographic procedure for determining urinary p-aminobenzoic acid (PABA) in the exocrine pancreatic function test. The urine specimen, collected for 6 h after oral administration of N-benzoyl-L-tyrosyl-p-aminobenzoic acid, is hydrolyzed in 4 mol/L NaOH containing m-hydroxybenzoic acid as...
Gianni Paulis et al.
Inflammation & allergy drug targets, 12(1), 61-67 (2012-09-26)
Peyronie's Disease (PD) is a connective tissue disorder involving the growth of fibrous plaques in penile corpora cavernosa (tunica albuginea). The conservative treatment is indicated in the development stage of PD for at least one year after diagnosis and in...
Yoshihiko Tashiro et al.
Blood, 119(26), 6382-6393 (2012-05-11)
Plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor of a major fibrinolytic factor, tissue-type plasminogen activator, can both promote and inhibit angiogenesis. However, the physiologic role and the precise mechanisms underlying the angiogenic effects of PAI-1 remain unclear. In the present...
Natalia Pozdnyakova et al.
Enzyme and microbial technology, 52(1), 44-53 (2012-12-04)
The inhibitor and substrate specificities of versatile peroxidase from Bjerkandera fumosa (VPBF) were studied. Two different effects were found: NaN(3), Tween-80, anthracene, and fluorene decreased the activity of VPBF, but p-aminobenzoic acid increased it. A mixed mechanism of effector influence...
L O Derewlany et al.
The Journal of pharmacology and experimental therapeutics, 269(2), 756-760 (1994-05-01)
The fetus is exposed to almost all of the substances found in the maternal circulation whether nutrients or foreign chemicals ("xenobiotics"). The main route of exposure is the placenta. The placenta is metabolically active toward xenobiotics and the nature of...
Steven C Bremmer et al.
Chemical communications (Cambridge, England), 48(44), 5482-5484 (2012-04-28)
A modular system for detecting protease activity via enzyme-triggered gel formation is described. Protease-specific recognition sequences are utilized to achieve enzyme specificity. Artificial blood clotting is demonstrated by activating endogenous thrombin to trigger gelation in fibrinogen-deficient blood plasma.
Huiming Zhang et al.
The Plant cell, 24(3), 1230-1241 (2012-03-27)
DNA methylation is a critical, dynamically regulated epigenetic mark. Small chemicals can be valuable tools in probing cellular processes, but the set of chemicals with broad effects on epigenetic regulation is very limited. Using the Arabidopsis thaliana repressor of silencing1...
Heidi C Schilter et al.
Respiratory research, 16, 42-42 (2015-04-19)
The persistent influx of neutrophils into the lung and subsequent tissue damage are characteristics of COPD, cystic fibrosis and acute lung inflammation. VAP-1/SSAO is an endothelial bound adhesion molecule with amine oxidase activity that is reported to be involved in...
L O Derewlany et al.
The Journal of pharmacology and experimental therapeutics, 269(2), 761-765 (1994-05-01)
Studies in our laboratory have shown that the N-acetylation activity of the human term placenta is a predominantly attributable to the NAT1 form of arylamine N-acetyltransferase (NAT). To further assess the acetylation capacity of the placenta, the N-acetylation of the...
Shu-Ting Chen et al.
Journal of the American Society for Mass Spectrometry, 23(8), 1408-1418 (2012-06-08)
A strategy based on negative ion electrospray ionization tandem mass spectrometry and closed-ring labeling with both 8-aminopyrene-1,3,6-trisulfonate (APTS) and p-aminobenzoic acid ethyl ester (ABEE) was developed for linkage and branch determination of high-mannose oligosaccharides. X-type cross-ring fragment ions obtained from...
Wei Zheng et al.
Sensors (Basel, Switzerland), 15(8), 18724-18741 (2015-08-13)
Resonant glassy nanostrings have been employed for the detection of biomolecules. These devices offer high sensitivity and amenability to large array integration and multiplexed assays. Such a concept has however been impaired by the lack of stable and biocompatible linker...
D Nathan et al.
Pharmaceutical research, 7(11), 1147-1151 (1990-11-01)
The percutaneous absorption and metabolism of three structurally related compounds, benzoic acid, p-aminobenzoic acid (PABA), and ethyl aminobenzoate (benzocaine), were determined in vitro through hairless guinea pig skin. Benzocaine was also studied in human skin. Absorption of benzocaine was rapid...
Wolfram Föllmann et al.
Journal of toxicology and environmental health. Part A, 75(19-20), 1206-1215 (2012-09-22)
N-Acetyltransferases (NAT) are important enzymes in the metabolism of certain carcinogenic arylamines, as N-acetylation decreases or prevents their bioactivation via N-hydroxylation. To study such processes in the bladder, cell culture models may be used, but metabolic competence needs to be...
Lauren LaBerge et al.
Dermatitis : contact, atopic, occupational, drug, 22(6), 332-334 (2012-06-02)
p-Phenylenediamine (PPD) is an important allergen; 5.0% of patients tested positive to PPD when patch-tested, according to the North American Contact Dermatitis Group. Hair dyes are the main source of exposure. To assess the significance of PPD allergy at the...
Helmieh Amine et al.
Marine pollution bulletin, 64(11), 2435-2442 (2012-09-18)
UVF may occur in the aquatic environment through two principal sources: direct inputs from recreational activities and indirect wastewater- and river-borne inputs. The aim of this study was to obtain a first overview of levels of three UVF (EHMC, OC...
A Q Zhang et al.
Luminescence : the journal of biological and chemical luminescence, 30(7), 1020-1025 (2015-02-26)
A reactive Tb(III) complex with p-aminobenzoic acid (p-ABA) and methacrylic acid (MAA) as ligands was synthesized. A novel copolymer was synthesized by free radical copolymerization of styrene and the reactive Tb(III) complex in dimethyl sulfoxide (DMSO) with 2,2'-azobis(2-methylpropionitrile) (AIBN) as...
L A Ramírez-Durán et al.
Current pharmaceutical design, 19(12), 2204-2215 (2012-09-29)
Myeloperoxidase (MPO) is the most abundant heme protein in neutrophils, and MPO catalyzes hypochlorous acid (HOCl) formation. MPO inhibitors (MPOis) can be used to treat several diseases in which MPO and HOCl levels are elevated. The molecular details of several...
Label free aptasensor for Lysozyme detection: A comparison of the analytical performance of two aptamers.
Cristina Ocaña et al.
Bioelectrochemistry (Amsterdam, Netherlands), 105, 72-77 (2015-05-27)
S Guerrero et al.
The Analyst, 140(22), 7527-7533 (2015-08-11)
The first electrochemical immunosensor for the determination of peptide YY is reported in this paper. A novel electrochemical platform, prepared by the electrochemical grafting of the diazonium salt of 4-aminobenzoic acid onto a reduced graphene oxide-modified glassy carbon electrode, was...
Kathy W K Tse et al.
Cellular immunology, 275(1-2), 47-54 (2012-04-18)
B-lymphocytes produce protective antibodies but also contribute to autoimmunity. In particular, marginal zone (MZ) B cells recognize both microbial components and self-antigens. B cell trafficking is critical for B cell activation and is controlled by chemoattactants such as CXCL13 and...
Xhorxhi Gjoka et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 972, 48-52 (2014-10-14)
Quantification of monoclonal antibody (mAb) monomer, mAb aggregates, and host cell proteins (HCPs) is critical for the optimization of the mAb production process. The present work describes a single high throughput analytical tool capable of tracking the concentration of mAb...
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